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Authors = Elizabeth A. Greener

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9 pages, 293 KiB  
Communication
Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children
by Todd A. Jusko, Kyra Singh, Elizabeth A. Greener, Marina Oktapodas Feiler, Kelly Thevenet-Morrison, B. Paige Lawrence, Robert O. Wright and Sally W. Thurston
Int. J. Environ. Res. Public Health 2019, 16(17), 3035; https://doi.org/10.3390/ijerph16173035 - 22 Aug 2019
Cited by 12 | Viewed by 3421
Abstract
Child blood lead concentrations have been associated with measures of immune dysregulation in nationally representative study samples. However, response to vaccination—often considered the gold standard in immunotoxicity testing—has not been examined in relation to typical background lead concentrations common among U.S. children. The [...] Read more.
Child blood lead concentrations have been associated with measures of immune dysregulation in nationally representative study samples. However, response to vaccination—often considered the gold standard in immunotoxicity testing—has not been examined in relation to typical background lead concentrations common among U.S. children. The present study estimated the association between blood lead concentrations and antigen-specific antibody levels to measles, mumps, and rubella in a nationally representative sample of 7005 U.S. children aged 6–17 years. Data from the 1999–2004 cycles of the National Health and Nutrition Examination Survey (NHANES) were used. In the adjusted models, children with blood lead concentrations between 1 and 5 µg/dL had an 11% lower anti-measles (95% CI: −16, −5) and a 6% lower anti-mumps antibody level (95% CI: −11, −2) compared to children with blood lead concentrations <1 µg/dL. The odds of a seronegative anti-measles antibody level was approximately two-fold greater for children with blood lead concentrations between 1 and 5 µg/dL compared to children with blood lead concentrations <1 µg/dL (OR = 2.0, 95% CI: 1.4, 3.1). The adverse associations observed in the present study provide further evidence of potential immunosuppression at blood lead concentrations <5 µg/dL, the present Centers for Disease Control and Prevention action level. Full article
(This article belongs to the Special Issue Maternal and Child Environmental Health and Disease)
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