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Authors = Efstratios Katsoulidis

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13 pages, 1015 KiB  
Review
Deregulation of Interferon Signaling in Malignant Cells
by Efstratios Katsoulidis, Surinder Kaur and Leonidas C. Platanias
Pharmaceuticals 2010, 3(2), 406-418; https://doi.org/10.3390/ph3020406 - 4 Feb 2010
Cited by 30 | Viewed by 17461
Abstract
Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs [...] Read more.
Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed. Full article
(This article belongs to the Special Issue Interferons)
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