Search Results (2)

Intravesical immunotherapy with Bacillus Calmette–Guerin (BCG) is a standard of care therapy for non-muscle invasive bladder cancer (NMIBC), which accounts for about 75% of newly diagnosed urothelial cancer. However, given the frequent recurrence and progression, identification of a pre-treatment biomarker capable of predicting responsiveness to BCG in NMIBC is of utmost importance. Herein, using multiparametric flow cytometry, we characterized CD8⁺ T cells from peripheral blood and tumor tissues collected from 27 pre-BCG patients bearing NMIBC to obtain immune correlates of bladder cancer prognosis and responsiveness to BCG therapy. We observed that intratumoral CD8⁺ T cell subsets were highly heterogenous in terms of their differentiation state and exist at different proportions in tumor tissues. Remarkably, among the different CD8⁺ T cell subsets present in the tumor tissues, the frequency of the terminally exhausted-like CD8⁺ T cell subset, marked as PD1⁺CD38⁺Tim3⁺ CD8⁺ T cells, was inversely correlated with a favorable outcome for patients and a responsiveness to BCG therapy. Moreover, we also noted that the intratumoral abundance of the progenitor exhausted-like PD1⁺CD8⁺ T cell subset in pre-BCG NMIBC tumor tissues was indicative of better recurrence-free survival after BCG. Collectively, our study led to the identification of biomarkers that can predict the therapeutic responsiveness of BCG in NMIBC. Full article

Papua New Guinea is blessed with a plethora of enviable natural resources, but at the same time it is also cursed by quite a few natural disasters like volcanic eruptions, earthquakes, landslide, floods, droughts etc. Floods happen to be a natural process of maintaining the health of the rivers and depth of its thalweg; it saves the river from becoming morbid while toning up the fertility of the riverine landscape. At the same time, from human perspective, all these ecological goodies are nullified when flood is construed overwhelmingly as one of the most devastating events in respect to social and economic consequences. The present investigation was tailored to assess the use of multi-criteria decision approach (MCDA) in inland flood risk analysis. Categorization of possible flood risk zones was accomplished using geospatial data sets, like elevation, slope, distance to river, and land use/land cover, which were derived from digital elevation model (DEM) and satellite image, respectively. A pilot study area was selected in the lower part of Markham River in Morobe Province, Papua New Guinea. The study area is bounded by 146°31′ to 146°58′ east and 6°33′ to 6°46′ south; covers an area of 758.30 km². The validation of a flood hazard risk map was carried out using past flood records in the study area. This result suggests that MCDA within GIS techniques is very useful in accurate and reliable flood risk analysis and mapping. This approach is convenient for the assessment of flood in any region, specifically in no-data regions, and can be useful for researchers and planners in flood mitigation strategies. Full article