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Authors = Daniil A. Buslaev

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5 pages, 577 KiB  
Short Note
Cis-(3-benzyloxy-1,1-cyclobutanedicarboxylato κ2O,O′)bis(1-methyl-1H-pyrazole)platinum(II)
by Anna S. Pavlova, Daniil A. Buslaev, Nataliya E. Borisova, Victor V. Temnov, Alexey A. Nazarov and Tatyana A. Podrugina
Molbank 2023, 2023(1), M1564; https://doi.org/10.3390/M1564 - 23 Jan 2023
Viewed by 1743
Abstract
A huge variety of types of cancer makes it necessary to search for new effective drugs with a defined molecular target. Modification of substituents in ligands based on 3-hydroxy-1,1-cyclobutanedicarboxylic acid are one of the effective directions to design a better version of carboplatin. [...] Read more.
A huge variety of types of cancer makes it necessary to search for new effective drugs with a defined molecular target. Modification of substituents in ligands based on 3-hydroxy-1,1-cyclobutanedicarboxylic acid are one of the effective directions to design a better version of carboplatin. In the present study, we combined in one molecule a derivative of 3-hydroxycyclobutane-1,1-dicarboxylic acid and N-methylpyrazole as a carrier ligand. The antiproliferative of the novel complex Pt(II) was established for cell lines HCT116, MCF7, A549, and WI38 by means of a standard MTT colorimetric assay. Full article
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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