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Authors = Arleta Glowacka-Sobotta

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31 pages, 42133 KiB  
Review
Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review
by Arleta Glowacka-Sobotta, Beata Czarczynska-Goslinska, Daniel Ziental, Marcin Wysocki, Maciej Michalak, Emre Güzel and Lukasz Sobotta
Nanomaterials 2024, 14(23), 1879; https://doi.org/10.3390/nano14231879 - 22 Nov 2024
Cited by 3 | Viewed by 1858
Abstract
Nanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Various nanoformulations, such as nanoparticles, nanocomposites, [...] Read more.
Nanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Various nanoformulations, such as nanoparticles, nanocomposites, and nanoemulsions, have been developed to enhance drug stability, solubility, and tissue penetration. Moreover, nanocarriers can be specifically engineered to target diseased cells or release the drug in a controllable manner, minimizing damage to surrounding healthy tissues and reducing side effects. This review focuses on the combinations between porphyrin derivatives and nanocarriers applied in photodynamic therapy (PDT). PDT has emerged as a significant advance in medicine, offering a low-invasive method for managing infections, the treatment of tumors, and various dermatoses. The therapy relies on the activation of a photosensitizer by light, which results in the generation of reactive oxygen species. Despite their favorable properties, porphyrins reveal non-specific distribution within the body. Nanotechnology has the capability to enhance the PS delivery and its activation. This review explores the potential improvements that are provided by the use of nanotechnology in the PDT field. Full article
(This article belongs to the Special Issue Laser-Matter Interaction for Nanostructuration: From Fundamentals to Optical, Electrochemical, Magnetic and Electrical Quantum Sensing)
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60 pages, 5372 KiB  
Review
Nanotechnology for Dentistry: Prospects and Applications
by Arleta Glowacka-Sobotta, Daniel Ziental, Beata Czarczynska-Goslinska, Maciej Michalak, Marcin Wysocki, Emre Güzel and Lukasz Sobotta
Nanomaterials 2023, 13(14), 2130; https://doi.org/10.3390/nano13142130 - 22 Jul 2023
Cited by 32 | Viewed by 7834
Abstract
In the XXI century, application of nanostructures in oral medicine has become common. In oral medicine, using nanostructures for the treatment of dental caries constitutes a great challenge. There are extensive studies on the implementation of nanomaterials to dental composites in order to [...] Read more.
In the XXI century, application of nanostructures in oral medicine has become common. In oral medicine, using nanostructures for the treatment of dental caries constitutes a great challenge. There are extensive studies on the implementation of nanomaterials to dental composites in order to improve their properties, e.g., their adhesive strength. Moreover, nanostructures are helpful in dental implant applications as well as in maxillofacial surgery for accelerated healing, promoting osseointegration, and others. Dental personal care products are an important part of oral medicine where nanomaterials are increasingly used, e.g., toothpaste for hypersensitivity. Nowadays, nanoparticles such as macrocycles are used in different formulations for early cancer diagnosis in the oral area. Cancer of the oral cavity—human squamous carcinoma—is the sixth leading cause of death. Detection in the early stage offers the best chance at total cure. Along with diagnosis, macrocycles are used for photodynamic mechanism-based treatments, which possess many advantages, such as protecting healthy tissues and producing good cosmetic results. Application of nanostructures in medicine carries potential risks, like long-term influence of toxicity on body, which need to be studied further. The introduction and development of nanotechnologies and nanomaterials are no longer part of a hypothetical future, but an increasingly important element of today’s medicine. Full article
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27 pages, 3878 KiB  
Review
Connections between Metallic Nanoparticles and Chlorin e6—An Overview of Physicochemical and Biological Properties and Prospective Medical Applications
by Tomasz Koczorowski, Arleta Glowacka-Sobotta, Maciej Michalak, Dariusz T. Mlynarczyk, Emre Güzel, Tomasz Goslinski and Lukasz Sobotta
Appl. Sci. 2023, 13(6), 3933; https://doi.org/10.3390/app13063933 - 20 Mar 2023
Cited by 3 | Viewed by 3598
Abstract
Photodynamic therapy is a non-invasive method of treatment for both neoplastic diseases and miscellaneous non-cancerous illnesses. It is complementary and, in some way, counter to various traditional treatment techniques, including chemotherapy, radiotherapy, and surgery. To date, various types of nanoparticles and compounds, including [...] Read more.
Photodynamic therapy is a non-invasive method of treatment for both neoplastic diseases and miscellaneous non-cancerous illnesses. It is complementary and, in some way, counter to various traditional treatment techniques, including chemotherapy, radiotherapy, and surgery. To date, various types of nanoparticles and compounds, including those belonging to the porphyrinoid group, have been researched in terms of future applications in technology and medicine. Among them, chlorins and their conjugates, combined with metallic nanoparticles, deserve special attention due to their enhanced photodynamic activity and the accompanied synergic photothermal effect. Many hybrid nanosystems reveal increased cellular uptake and improved stability and, therefore, can be applied in enhanced MRI imaging, as well as in targeting therapy. This review is focused on conjugates of metallic nanoparticles and chlorins, having in mind prospective applications as photosensitizers in multimodal neoplastic therapy, as well as tumor diagnosis. Full article
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31 pages, 5150 KiB  
Review
BODIPY-Based Nanomaterials—Sensing and Biomedical Applications
by Tomasz Koczorowski, Arleta Glowacka-Sobotta, Stepan Sysak, Dariusz T. Mlynarczyk, Roman Lesyk, Tomasz Goslinski and Lukasz Sobotta
Appl. Sci. 2022, 12(15), 7815; https://doi.org/10.3390/app12157815 - 3 Aug 2022
Cited by 12 | Viewed by 4274
Abstract
Cancerous diseases are rightfully considered among the most lethal, which have a consistently negative effect when considering official statistics in regular health reports around the globe. Nowadays, metallic nanoparticles can be potentially applied in medicine as active pharmaceuticals, adjustable carriers, or distinctive enhancers [...] Read more.
Cancerous diseases are rightfully considered among the most lethal, which have a consistently negative effect when considering official statistics in regular health reports around the globe. Nowadays, metallic nanoparticles can be potentially applied in medicine as active pharmaceuticals, adjustable carriers, or distinctive enhancers of physicochemical properties if combined with other drugs. Boron dipyrromethene (BODIPY) molecules have been considered for future applications in theranostics in the oncology field, thus expanding the potential of conceivable applicability. Hence, taking into account positive practical features of both metal-based nanostructures and BODIPY derivatives, the present study aims to gather recent results connected to BODIPY-conjugated metallic nanoparticles. This is with respect to their expediency in the diagnosis and treatment of tumor ailments as well as in sensing of heavy metals. To fulfill the designated objectives, multiple research documents were analyzed concerning the latest discoveries within the scope of BODIPY-based nanomaterials with particular emphasis on their utilization for diagnostical sensing as well as cancer diagnostics and therapy. In addition, collected examples of mentioned conjugates were presented in order to draw the attention of the scientific community to their practical applications, elucidate the topic in a consistent manner, and inspire fellow researchers for new findings. Full article
(This article belongs to the Special Issue Heterocyclic Compounds with Potential Biological Activity - Volume II)
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15 pages, 1389 KiB  
Article
Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria
by Magdalena Stolarska, Arleta Glowacka-Sobotta, Dariusz T. Mlynarczyk, Jolanta Dlugaszewska, Tomasz Goslinski, Jadwiga Mielcarek and Lukasz Sobotta
Int. J. Mol. Sci. 2020, 21(17), 6145; https://doi.org/10.3390/ijms21176145 - 26 Aug 2020
Cited by 15 | Viewed by 2259
Abstract
Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical properties against wound bacteria. In the UV-vis spectra of analyzed tribenzoporphyrazines, typical absorption ranges were found. However, the emission properties were very weak, with fluorescence quantum yields in the [...] Read more.
Magnesium(II) tribenzoporphyrazines with phenoxybutylsulfanyl substituents were evaluated as photosensitizers in terms of their optical properties against wound bacteria. In the UV-vis spectra of analyzed tribenzoporphyrazines, typical absorption ranges were found. However, the emission properties were very weak, with fluorescence quantum yields in the range of only 0.002–0.051. What is important, they revealed moderate abilities to form singlet oxygen with the quantum yields up to 0.27. Under irradiation, the macrocycles decomposed via photobleaching mechanism with the quantum yields up to 8.64 × 10−5. The photokilling potential of tribenzoporphyrazines was assessed against Streptococcus pyogenes, Staphylococcus epidermidis, as well as various strains of Staphylococcus aureus, including methicillin-sensitive and-resistant bacteria. Both evaluated photosensitizers revealed high photodynamic potential against studied bacteria (>3 logs). S.aureus growth was reduced by over 5.9 log, methicillin-resistant S. aureus by 5.1 log, S.epidermidis by over 5.7 log, and S. pyogenes by over 4.7 log. Full article
(This article belongs to the Section Molecular Biophysics)
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31 pages, 2810 KiB  
Review
Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine
by Daniel Ziental, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Arleta Glowacka-Sobotta, Beata Stanisz, Tomasz Goslinski and Lukasz Sobotta
Nanomaterials 2020, 10(2), 387; https://doi.org/10.3390/nano10020387 - 23 Feb 2020
Cited by 532 | Viewed by 36755
Abstract
Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) [...] Read more.
Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review. Full article
(This article belongs to the Section Biology and Medicines)
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