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Aim: To evaluate the effect of the resin-bonded prosthesis (Maryland bridge) on marginal bone remodeling of implants placed at the tissue level in the posterior region. Methods: Consecutive healthy patients (n = 46) were included in this clinical study. Flapless not-submerged implants were placed with cover screws exposed and positioned approximately 0.5 mm above tissue level. Patients received the implant and a temporary resin-bonded prosthesis (RBP) (n = 22) or only the implant (n = 24). The RBPs were kept in place for 3 months and removed before impressions. The implants received a custom-made abutment and provisional resin crowns followed by definitive cemented metal–ceramic crowns after 2–3 weeks. The marginal bone level (MBL) was evaluated in a single-blind condition on scanned periapical radiographs and assessed mesially and distally (MBL-M/MBL-D). The bone levels of adjacent teeth (CEJ-M/CEJ-D) and the modification of the area between the implant and the mesial/distal teeth (Area-M/Area-D) were measured. All measurements were made at 1, 3 (pre-loading time) and 12 months (post-loading time). Linear regression models were fitted to evaluate the existence of any significant difference. Results: A total of 44 patients (20 Female, 24 Male; Mean age: 53.9 ± 10.3) completed the study. Two patients were excluded for fractured RBP or de-bonding. The drop-out was of 4.3%. After 12 months, all implants were free from complications. No peri-implantitis or mucositis were observed. The RBP group showed the most stable MBL at 12 months (−0.07 ± 0.41), statistically different from the non-RBP group (−0.67 ± 0.52). CEJ-M and CEJ-D were stable in both groups. Conclusion: The proposed approach of the use of RBP creates a more stable marginal bone level around implants placed at the tissue level, resulting in a reliable technique to protect bone tissue from mechanical and occlusal trauma during the healing period and osteointegration. Full article