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Authors = Anna Rezacova

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15 pages, 412 KiB  
Article
Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives
by Zbynek Oktabec, Jiri Kos, Zuzana Mandelova, Lenka Havelkova, Tomas Pekarek, Anna Rezacova, Lukas Placek, Marcela Tkadlecova, Jaroslav Havlicek, Jiri Dohnal and Josef Jampílek
Molecules 2010, 15(12), 8973-8987; https://doi.org/10.3390/molecules15128973 - 8 Dec 2010
Cited by 10 | Viewed by 7648
Abstract
Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically [...] Read more.
Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-d-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed. Full article
(This article belongs to the Special Issue ECSOC-13)
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