Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Authors = Alice Valença Araújo ORCID = 0000-0002-9728-8033

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
26 pages, 1247 KiB  
Review
Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors
by Gabriela Maria da Silva, Mirelly Cunha da Silva, Déborah Victória Gomes Nascimento, Ellen Mayara Lima Silva, Fabíola Furtado Fialho Gouvêa, Luiz Gonzaga de França Lopes, Alice Valença Araújo, Kelli Nogueira Ferraz Pereira and Thyago Moreira de Queiroz
Biology 2021, 10(10), 1041; https://doi.org/10.3390/biology10101041 - 14 Oct 2021
Cited by 65 | Viewed by 23254
Abstract
Cardiovascular diseases include all types of disorders related to the heart or blood vessels. High blood pressure is an important risk factor for cardiac complications and pathological disorders. An increase in circulating angiotensin-II is a potent stimulus for the expression of reactive oxygen [...] Read more.
Cardiovascular diseases include all types of disorders related to the heart or blood vessels. High blood pressure is an important risk factor for cardiac complications and pathological disorders. An increase in circulating angiotensin-II is a potent stimulus for the expression of reactive oxygen species and pro-inflammatory cytokines that activate oxidative stress, perpetuating a deleterious effect in hypertension. Studies demonstrate the capacity of NO to prevent platelet or leukocyte activation and adhesion and inhibition of proliferation, as well as to modulate inflammatory or anti-inflammatory reactions and migration of vascular smooth muscle cells. However, in conditions of low availability of NO, such as during hypertension, these processes are impaired. Currently, there is great interest in the development of compounds capable of releasing NO in a modulated and stable way. Accordingly, compounds containing metal ions coupled to NO are being investigated and are widely recognized as having great relevance in the treatment of different diseases. Therefore, the exogenous administration of NO is an attractive and pharmacological alternative in the study and treatment of hypertension. The present review summarizes the role of nitric oxide in hypertension, focusing on the role of new NO donors, particularly the metal-based drugs and their protagonist activity in vascular function. Full article
Show Figures

Figure 1

Back to TopTop