As all of the articles published in our journal are open access, you have free and unlimited access to the full text. We welcome you to read our most highly cited papers published in 2024 and 2025, which are listed below:

1. “Fingerprinting Interactions between Proteins and Ligands for Facilitating Machine Learning in Drug Discovery”
by Zoe Li, Ruili Huang, Menghang Xia, Tucker A. Patterson and Huixiao Hong
Biomolecules 2024, 14(1), 72; https://doi.org/10.3390/biom14010072  
Full text available online: https://www.mdpi.com/2218-273X/14/1/72

2. “Green Synthesis of Silver Nanoparticles with Extracts from Kalanchoe fedtschenkoi: Characterization and Bioactivities”
by Jorge L. Mejía-Méndez, Gildardo Sánchez-Ante, Mónica Cerro-López, Yulianna Minutti-Calva, Diego E. Navarro-López, J. Daniel Lozada-Ramírez, Horacio Bach, Edgar R. López-Mena and Eugenio Sánchez-Arreola
Biomolecules 2024, 14(7), 782; https://doi.org/10.3390/biom14070782
Full text available online: https://www.mdpi.com/2218-273X/14/7/782

3. “Harnessing Nanotechnology: Emerging Strategies for Multiple Myeloma Therapy”
by Min Yang, Yu Chen, Li Zhu, Liangshun You, Hongyan Tong, Haitao Meng, Jianpeng Sheng and  Jie Jin
Biomolecules 2024, 14(1), 83; https://doi.org/10.3390/biom14010083  
Full text available online: https://www.mdpi.com/2218-273X/14/1/83

4. “Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia”
by Emanuele Marzetti, Biliana Lozanoska-Ochser, Riccardo Calvani, Francesco Landi, Hélio José Coelho-Júnior and Anna Picca
Biomolecules 2024, 14(4), 415; https://doi.org/10.3390/biom14040415  
Full text available online: https://www.mdpi.com/2218-273X/14/4/415

5. “Iron Dysregulation in Alzheimer’s Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus”
by Susana Junceda, María Cruz-Alonso, Beatriz Fernandez, Rosario Pereiro, Eva Martínez-Pinilla and Ana Navarro
Biomolecules 2024, 14(3), 295; https://doi.org/10.3390/biom14030295  
Full text available online: https://www.mdpi.com/2218-273X/14/3/295

6. “Antimicrobial Potency of Fmoc-Phe-Phe Dipeptide Hydrogels with Encapsulated Porphyrin Chromophores Is a Promising Alternative in Antimicrobial Resistance”
by Chrysanthi Pinelopi Apostolidou, Chrysoula Kokotidou, Varvara Platania, Vasilis Nikolaou, Georgios Landrou, Emmanouil Nikoloudakis, Georgios Charalambidis, Maria Chatzinikolaidou, Athanassios G. Coutsolelos and Anna Mitraki
Biomolecules 2024, 14(2), 226; https://doi.org/10.3390/biom14020226  
Full text available online: https://www.mdpi.com/2218-273X/14/2/226

7. “Recent Advances in Hydrogel-Based 3D Bioprinting and Its Potential Application in the Treatment of Congenital Heart Disease”
by Tasneem Salih, Massimo Caputo and Mohamed T. Ghorbel
Biomolecules 2024, 14(7), 861; https://doi.org/10.3390/biom14070861  
Full text available online: https://www.mdpi.com/2218-273X/14/7/861

8. “Organocyclophosphazenes and Materials Based on Them for Pharmaceuticals and Biomedicine”
by Pavel Yudaev, Anton Tupikov and Evgeniy Chistyakov
Biomolecules 2025, 15(2), 262; https://doi.org/10.3390/biom15020262  
Full text available online: https://www.mdpi.com/2218-273X/15/2/262

9. “Bioactive Materials in Vital Pulp Therapy: Promoting Dental Pulp Repair Through Inflammation Modulation”
by Liang Qiao, Xueqing Zheng, Chun Xie, Yaxin Wang, Lu Ye, Jiajia Zhao and Jiarong Liu
Biomolecules 2025, 15(2), 258; https://doi.org/10.3390/biom15020258  
Full text available online: https://www.mdpi.com/2218-273X/15/2/258

10. “Hydrogels with Ultrasound-Treated Hyaluronic Acid Regulate CD44-Mediated Angiogenic Potential of Human Vascular Endothelial Cells In Vitro”
by Kelum Chamara Manoj Lakmal Elvitigala, Wildan Mubarok and Shinji Sakai
Biomolecules 2024, 14(5), 604; https://doi.org/10.3390/biom14050604   
Full text available online: https://www.mdpi.com/2218-273X/14/5/604