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Novel Toxicity Aspects of Cyanotoxins  †

Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain
Author to whom correspondence should be addressed.
Presented at the 7th Iberian Congress on Cyanotoxins/3rd Iberoamerican Congress on Cyanotoxins, Ponta Delgada, Portugal, 18–20 July 2022.
Presenting author (key-note talk).
Biol. Life Sci. Forum 2022, 14(1), 10;
Published: 19 July 2022


The occurrence of toxic cyanobacteria and their cyanotoxins production are increasing phenomena reported worldwide. Cyanotoxins, secondary metabolites of different cyanobacterial species, are considered a potential hazard that can become a risk for human and environmental health after exposure. Global changes (rising temperatures, eutrophication due to human activities, etc.) favour their appearance leading to increased exposures and, consequently, risks. In order to avoid their negative impacts, the World Health Organization has established provisional drinking-water and recreational-water guideline values, and different countries have implemented limits in their regulations. However, these limits are not enough taking into account the increasing number of known cyanotoxins. Also, the establishment of these legal limits is hampered by the gaps in the knowledge of their toxicological profiles. Thus, this work aimed to establish the state of the art on the human toxicity of cyanotoxins (mainly microcystins, cylindrospermopsin and anaxotin-A) and to shed light on aspects not completely elucidated, such as target organ toxicity, immunotoxicity or genotoxicity.

Author Contributions

Conceptualization, A.J. and A.M.C.; methodology, A.I.P. and M.P.; formal analysis and investigation, A.C.-R., C.P.-C., L.D.-Q. and C.M.-P.; resources, A.J. and A.M.C.; writing-original draft preparation, A.J.; writing review and editing, A.M.C.; project administration, A.J. and A.M.C.; funding acquisition, A.J. and A.M.C. All authors have read and agreed to the published version of the manuscript.


The Spanish Ministerio de Ciencia e Innovación (PID2019-104890RB-I00 MICIN/ AEI/10.13039/ 501100011033) for the financial support. A.C.-R. thanks to the MICINN for the predoctoral grant (PRE2020-094412). C.P.-C. thanks to the Junta de Andalucía for the predoctoral grant (PREDOC_00447) and L.D.-Q. thanks to the Junta de Andalucía for the grant (POSTDOC_21_00130).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Conflicts of Interest

The authors declare no conflict of interest.
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MDPI and ACS Style

Jos, A.; Casas-Rodríguez, A.; Plata-Calzado, C.; Diez-Quijada, L.; Medrano-Padial, C.; Puerto, M.; Prieto, A.I.; Cameán, A.M. Novel Toxicity Aspects of Cyanotoxins . Biol. Life Sci. Forum 2022, 14, 10.

AMA Style

Jos A, Casas-Rodríguez A, Plata-Calzado C, Diez-Quijada L, Medrano-Padial C, Puerto M, Prieto AI, Cameán AM. Novel Toxicity Aspects of Cyanotoxins . Biology and Life Sciences Forum. 2022; 14(1):10.

Chicago/Turabian Style

Jos, Angeles, Antonio Casas-Rodríguez, Cristina Plata-Calzado, Leticia Diez-Quijada, Concepción Medrano-Padial, María Puerto, Ana I. Prieto, and Ana M. Cameán. 2022. "Novel Toxicity Aspects of Cyanotoxins " Biology and Life Sciences Forum 14, no. 1: 10.

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