Effects of Diet and Exercise on Metabolic Parameters and Health in Moderate to Advanced Kidney Disease
Round 1
Reviewer 1 Report
The manuscript “Effects of diet and exercise on metabolic parameters and health in moderate to advanced kidney disease” is an excellent review focusing on the role of dietary intervention and exercise on metabolic, inflammatory and oxidative stress parameters in patients with advanced CKD.
The authors present several aspects of dietary interventions and of physical activity in a well organized and comprehensive manner. I consider this paper to be of high interest for the readers and I would recommend it for publication as it is.
Just one minor remark: page 2 rows 82-83 – “aerobic restriction” should be probably “aerobic exercise”.
Author Response
We thank the author for the review and the kind words. We have corrected the wording accordingly.
Reviewer 2 Report
I read with interest the review by Ertlugu and Izikler on the effects of diet and exercise in CKD.
I only have two minor comments:
- Line 328: pay attention and amend the following mistake: “numerous studies pilot studies”;
- In the conclusion, the Authors state that “caloric restriction and healthy dietary patterns may improve dyslipidemia, inflammation and oxidative burdens in patients with CKD without leading to protein energy wasting or electrolyte disturbances”. Since in the previous sentence, the Authors talk about both “non-dialysis and dialysis-dependent CKD”, I would suggest specifying the differences in dietary recommendations for CKD patients not on dialysis and MHD ones (just not to give the idea that “one size fits all”).
Author Response
We thank the reviewer for the comments. We have corrected the wording in line 328 and changed the sentence in the conclusion as follows: "Caloric restriction and healthy dietary habits may improve dyslipidemia, inflammation and oxidative burdens in patients with non-dialysis dependent CKD. Adherence to healthy dietary patterns may benefit dialysis dependent patients similarly without leading to protein energy wasting or electrolyte disturbances." according to the suggestions.
