Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma
Abstract
:1. Introduction
2. Materials and Methods
2.1. Case Selection
2.2. DNA/RNA Preparation
2.3. Gene Expression Analysis
2.4. Mutation Analysis
2.5. Analysis of IG Gene Rearrangements
3. Results
3.1. Gene Expression Analysis by HTG EdgeSeq
3.2. Mutation Analysis
3.3. Analysis of IG Gene Rearrangements
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene | Transcript ID | BL | DLBCL | HGBL DH | HGBL NOS |
---|---|---|---|---|---|
ARID1A | NM_006015 | Q487*; R693*; Q1145Rfs*16; P1898Hfs*25 2 | A345_A349del; Q564*; P887L; Y1233H; P1898Hfs*25 | R1528*; R2116T | Q74*; Q1145Rfs*16 |
ATM | NM_000051 | - | K2810Q | - | C1811Y |
B2M | NM_004048 | - | M1V | - | - |
BCL2 | NM_000657 | - | H3L; H58R; A67G; P78L; V92A; H120E; F124C | G5A; N11T; R12W; D31G; G47D; Q52L; A60D; P90S; N182D; G197S | - |
BCL6 | NM_001706 | - | R526C | Q397* | - |
BRAF | NM_004333 | - | G469E | - | G466E |
CARD11 | NM_032415 | - | R235P; G757V | - | R235P |
CD79B | NM_001039933 | - | M191L; Y197C; Y197H; Y197S; Y208* | - | - |
CDKN2A | NM_000077 | - | V82M | R80* | - |
CREBBP | NM_004380 | - | Y1503F | Q1073Vfs*13; R1173*; V1371D; S1436R; R1446H; P1494R; R1498Q; D1543V | - |
EZH2 | NM_004456 | - | Y646F; Y646N | Y646F 2 | - |
GNA13 | NM_006572 | Q27*; H345R | V221L; N263K; L342_F346delins* | Q28*; N91D; L184P; R260*; V362M | - |
HIST1H1E | NM_005321 | - | P118S 2; A123T 2; T142S; A167G; P201A | G103A | G103R; A165V |
KMT2D | NM_003482 | - | c.15784+1G>A; c.4693+6T>A; L1199Hfs*7; Q1893*; R2771*; I3421Mfs*12; P3466Tfs*2; Q3609*; R5048C | Q2416*; R2801*; R2847H; Q4732*; Q5003* | - |
MTOR | NM_004958 | - | W1456R | - | - |
MYC | NM_002467 | Q50H; E54D; T73S; F153C; L191F; S217_S218delinsIN; S264R | P72S; T73A; P75T; Q194H | Q10H; Q51_E54delinsHQID; S53I; P72S; T73I; V92I; K158N; N451K | S21N; N26T; E54D 2; T73I; S107R; E137D; G152A; S187C |
MYD88 | NM_002468 | - | S219C; L265P 2 | - | L265P |
PIM1 | NM_001243186 | - | c.513+1G>A; c.880+1G>A; Q30L; G73D; Y129*; Q130*; V217M; L273F; [c.880+5G>A; Q128H; P172S; P178S; L184V; S188R; Q218K; I224Gfs*74; L265F; L323V]Case 46 | N251I | I147_S150del; E161Q; S188T; [c.514-1_521 delinsACCTAATGA; V90F; G91E; G119_P124delins DKKKEA; P124A; G139D; M179I; S188N; L197F; V217_D219delinsLQH; Q218*; E226K; Q231*; V242I; L275F; R312K; C361Y]Case 48 |
SOCS1 | NM_003745 | - | A16S; Y64Afs*48; S116_V117delinsRL | E24D; Y64N; C111W | A3T; A3V; R59H; D138H; Y154_R170del; M161I |
TNFAIP3 | NM_001270508 | - | C103*; F152Lfs*64 | - | - |
TNFRSF14 | NM_003820 | - | V239I | c.50_69+1delinsGAACCGACGT; Y61*; N110S | - |
TP53 | NM_000546 | D281E | A138V; R181P; R196*; Y234C; R273H; R273G | K139N; Y234D | - |
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Faißt, K.D.; Husemann, C.C.; Kleo, K.; Twardziok, M.; Hummel, M. Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma. J. Mol. Pathol. 2024, 5, 415-436. https://doi.org/10.3390/jmp5040028
Faißt KD, Husemann CC, Kleo K, Twardziok M, Hummel M. Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma. Journal of Molecular Pathology. 2024; 5(4):415-436. https://doi.org/10.3390/jmp5040028
Chicago/Turabian StyleFaißt, Katharina D., Cora C. Husemann, Karsten Kleo, Monika Twardziok, and Michael Hummel. 2024. "Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma" Journal of Molecular Pathology 5, no. 4: 415-436. https://doi.org/10.3390/jmp5040028
APA StyleFaißt, K. D., Husemann, C. C., Kleo, K., Twardziok, M., & Hummel, M. (2024). Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma. Journal of Molecular Pathology, 5(4), 415-436. https://doi.org/10.3390/jmp5040028