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The Birth of the Journal of Molecular Pathology
Open AccessHypothesis

Are Microsatellite Patterns Specific for Tumor Types? A Pilot Investigation

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Kliniken der Stadt Köln, Klinikum der Privaten Universität Witten, Ostmerheimer Str. 200, 51109 Köln (Cologne), Germany
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GENOPATH GbR, Heilsbachstraße 15, 53123 Bonn, Germany
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Authors to whom correspondence should be addressed.
J. Mol. Pathol. 2020, 1(1), 3-8; https://doi.org/10.3390/jmp1010002
Received: 22 July 2020 / Revised: 31 August 2020 / Accepted: 1 September 2020 / Published: 4 September 2020
Microsatellite testing is an emerging field of molecular pathology, as microsatellite instability (MSI) appears to be a predictive biomarker for some cancers. Although multiple studies on microsatellites have been published, recent observations suggest that the microsatellites that define instability differ between tumor entities. This assumption is confirmed by the present study that compared different MSI assays validated for colorectal cancer. Whilst all assays deliver the same MSI/MSS status for colorectal cancers, they differ for tonsillar tumors, leading to the hypothesis that MSI patterns are tumor-type specific. View Full-Text
Keywords: microsatellite instability; MSI; colorectal cancer; tonsillar tumors; MSI pattern microsatellite instability; MSI; colorectal cancer; tonsillar tumors; MSI pattern
MDPI and ACS Style

Haiduk, T.; Brockmann, M.; Schmitt, C.; Tillmann, R.-L.; Pieper, M.; Lüsebrink, J.; Schildgen, O.; Schildgen, V. Are Microsatellite Patterns Specific for Tumor Types? A Pilot Investigation. J. Mol. Pathol. 2020, 1, 3-8.

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