Retrospective Analysis of Vitamin D Levels in Girls with Idiopathic Central Precocious Puberty: A Potential Role in Pubertal Activation?
Abstract
1. Introduction
2. Materials and Methods
2.1. Reference Values for Anthropometric and Biochemical Parameters
2.2. Ethical Issues
2.3. Statistical Analysis
3. Results
3.1. Clinical and Auxological Characteristics by Vitamin D Status
3.2. Correlation Analysis
3.3. Multiple Linear Regression Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | <20 ng/mL (n = 47) | 20–30 ng/mL (n = 50) | >30 ng/mL (n = 25) | p-Value |
---|---|---|---|---|
Age at diagnosis (years) | 6.95 ± 0.63 | 6.92 ± 0.63 | 6.99 ± 0.73 | 0.86 |
Height (cm) | 122.1 ± 5.8 | 121.3 ± 6.4 | 122.6 ± 5.9 | 0.74 |
Height SDS | 1.18 ± 0.78 | 1.05 ± 0.81 | 1.12 ± 0.84 | 0.63 |
Weight (kg) | 25.6 ± 4.9 | 25.0 ± 5.2 | 24.5 ± 4.6 | 0.48 |
Weight SDS | 0.71 ± 0.89 | 0.64 ± 1.11 | 0.59 ± 1.06 | 0.62 |
BMI | 17.1 ± 2.0 | 16.9 ± 2.1 | 16.6 ± 1.9 | 0.40 |
BMI SDS | 0.81 ± 0.86 | 0.75 ± 1.17 | 0.60 ± 0.92 | 0.39 |
Growth velocity SDS | 1.60 ± 0.65 | 1.44 ± 0.63 | 1.53 ± 0.68 | 0.27 |
Basal LH (mIU/mL) | 0.42 ± 0.27 | 0.46 ± 0.30 | 0.50 ± 0.28 | 0.19 |
Basal FSH (mIU/mL) | 2.62 ± 1.15 | 2.76 ± 1.08 | 2.88 ± 1.14 | 0.37 |
LH Peak (mIU/mL) | 11.18 ± 4.40 | 12.61 ± 3.76 | 12.48 ± 4.34 | 0.16 |
LH/FSH ratio | 1.46 ± 0.59 | 1.64 ± 1.45 | 1.86 ± 1.13 | 0.06 |
Variable | Spearman’s Rho | p-Value |
---|---|---|
LH Peak (mIU/mL) | 0.23 | 0.037 |
LH/FSH ratio | 0.11 | 0.31 |
Basal LH (mIU/mL) | 0.15 | 0.10 |
BMI SDS | −0.08 | 0.45 |
Growth velocity SDS | 0.07 | 0.56 |
Height SDS | 0.05 | 0.64 |
Age at diagnosis | −0.02 | 0.80 |
Predictor | β Coefficient | Standard Error | t-Value | p-Value |
---|---|---|---|---|
Intercept | 10.42 | 4.31 | 2.42 | 0.017 |
Vitamin D (ng/mL) | 0.125 | 0.059 | 2.12 | 0.036 |
BMI SDS | −0.002 | 0.345 | −0.01 | 0.995 |
Growth velocity SDS | −0.068 | 0.566 | −0.12 | 0.905 |
Age at diagnosis | −0.163 | 0.569 | −0.29 | 0.775 |
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Sodero, G.; Moscogiuri, L.A.; Camporeale, A.; Meoli, A.; Comes, F.; Passoforte, P.; Perrone, G.; Villirillo, A.; Lezzi, M. Retrospective Analysis of Vitamin D Levels in Girls with Idiopathic Central Precocious Puberty: A Potential Role in Pubertal Activation? Endocrines 2025, 6, 33. https://doi.org/10.3390/endocrines6030033
Sodero G, Moscogiuri LA, Camporeale A, Meoli A, Comes F, Passoforte P, Perrone G, Villirillo A, Lezzi M. Retrospective Analysis of Vitamin D Levels in Girls with Idiopathic Central Precocious Puberty: A Potential Role in Pubertal Activation? Endocrines. 2025; 6(3):33. https://doi.org/10.3390/endocrines6030033
Chicago/Turabian StyleSodero, Giorgio, Luigi Antonio Moscogiuri, Anna Camporeale, Aniello Meoli, Fabio Comes, Paola Passoforte, Giacomo Perrone, Antonietta Villirillo, and Marilea Lezzi. 2025. "Retrospective Analysis of Vitamin D Levels in Girls with Idiopathic Central Precocious Puberty: A Potential Role in Pubertal Activation?" Endocrines 6, no. 3: 33. https://doi.org/10.3390/endocrines6030033
APA StyleSodero, G., Moscogiuri, L. A., Camporeale, A., Meoli, A., Comes, F., Passoforte, P., Perrone, G., Villirillo, A., & Lezzi, M. (2025). Retrospective Analysis of Vitamin D Levels in Girls with Idiopathic Central Precocious Puberty: A Potential Role in Pubertal Activation? Endocrines, 6(3), 33. https://doi.org/10.3390/endocrines6030033