Processing Stability and the Significance of Variation in Extrusion Speeds and Temperatures on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Hot Melt Extrusion Conditions
2.2. Differential Scanning Calorimetry (DSC)
2.3. Rheological Analysis
2.4. Swelling/Degradation Studies
3. Results
3.1. Hot Melt Extrusion
3.2. Differential Scanning Calorimetry
3.3. Rheological Analysis
3.4. Swelling Studies of Variation in Screw Speed and Extrusion Temperature on a Novel SSB® 55 Pharma Grade Shellac
4. Discussion
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Screw Speed (RPM) | Temperature (°C) | ||||||
---|---|---|---|---|---|---|---|
Zone 1 | Zone 2 | Zone 3 | Zone 4 | Zone 5 | Zone 6 | Die | |
100 | 30 | 35 | 40 | 50 | 60 | 65 | 70 |
Screw Speed (RPM) | Temperature (°C) | |||||||
---|---|---|---|---|---|---|---|---|
Zone 1 | Zone 2 | Zone 3 | Zone 4 | Zone 5 | Zone 6 | Die | ||
50 | Temp. 1 | 30 | 35 | 40 | 50 | 60 | 65 | 70 |
50 | Temp. 2 | 40 | 45 | 50 | 60 | 70 | 80 | 90 |
Sample | Peak Temperature (°C) | Enthalpy (J/g) | Relative Crystallinity (%) |
---|---|---|---|
Base Material | 56.47 | 3.61 | 100.00 |
25 rpm | 44.32 | 7.55 | 208.88 |
50 rpm | 45.63 | 8.28 | 229.09 |
100 rpm | 45.30 | 8.60 | 237.95 |
150 rpm | 44.48 | 8.31 | 229.98 |
200 rpm | 44.56 | 9.07 | 250.93 |
Sample | Temp Profile 1 (Tm °C) | Temp Profile 2 (Tm °C) | Temp. Profile 1 Enthalpy (J/g) | Temp. Profile 2 Enthalpy (J/g) |
---|---|---|---|---|
25 rpm | 44.32 | 44.57 | 9.47 | 8.99 |
50 rpm | 45.63 | 45.34 | 7.09 | 6.64 |
100 rpm | 45.30 | 45.17 | 9.42 | 8.99 |
150 rpm | 44.48 | 45.37 | 8.25 | 8.81 |
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Gately, N.M.; Kennedy, J.E. Processing Stability and the Significance of Variation in Extrusion Speeds and Temperatures on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery. J. Manuf. Mater. Process. 2017, 1, 9. https://doi.org/10.3390/jmmp1010009
Gately NM, Kennedy JE. Processing Stability and the Significance of Variation in Extrusion Speeds and Temperatures on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery. Journal of Manufacturing and Materials Processing. 2017; 1(1):9. https://doi.org/10.3390/jmmp1010009
Chicago/Turabian StyleGately, Noel M., and James E. Kennedy. 2017. "Processing Stability and the Significance of Variation in Extrusion Speeds and Temperatures on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery" Journal of Manufacturing and Materials Processing 1, no. 1: 9. https://doi.org/10.3390/jmmp1010009