Next Article in Journal
A study on Antioxidant Properties of Different Extracts from Kitaibelia balansae
Previous Article in Journal
Foliar Nutrient Management on Potato Grown under Zero Tillage and Mulching in Coastal Saline Soil of West Bengal, India
Open AccessAbstract

The Effect of Trichostatin A on Radiosensitivity in Glioblastoma

1
Department of Medical Biology, Faculty of Medicine, Aksaray University, 68100 Aksaray, Turkey
2
Department of Medical Biology, Faculty of Medicine, Van Yuzuncu Yil University, 65100 Van, Turkey
3
Department of Biophysics, Faculty of Medicine, Van Yuzuncu Yil University, 65100 Van, Turkey
4
Faculty of Medicine, Van Yuzuncu Yil University, 65100 Van, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 3rd International conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 18–20 December 2019.
Proceedings 2019, 40(1), 22; https://doi.org/10.3390/proceedings2019040022
Published: 26 December 2019
Glioblastoma (GB) is the most lethal brain tumor that resists standard treatments because of its high malignancy. Radiotherapy (RT) directly affects the clinical success on GB treatment. Epigenetic modifications occur in GB cells at a high rate. Improving the therapeutic efficacy of RT over epigenetic modulators may contribute to the development of a targeted treatment in GB. Trichostatin A (TSA), a histone deacetylase inhibitor, a natural antifungal compound. The aim of this study was to investigate the effect of TSA on radiosensitivity when combined with RT in GB cells. Different concentrations of TSA (in the range of 100–1000 nm) and 8 Gy RT were applied to GB LN-405 cells as alone and combination simultaneously. Cell viability was determined by MTT. In the RT application, 3D conformal technique, which can represent GB clinical practice, was used. Cell viability was significantly reduced in both TSA and TSA + RT combination groups compared to control group (p < 0.05). When the TSA was compared with the TSA + RT combination, it was found that TSA increased the radiosensitivity by 17–41% depending on the dose. This is the first study to show that TSA increases the radiosensitivity in GB LN-405 cells in the literature.
Keywords: glioblastoma; Trichostatin A; radiosensitivity glioblastoma; Trichostatin A; radiosensitivity
MDPI and ACS Style

Taspinar, M.; Çakir, T.; Güven, M.; Denizler, F.N.; Kartal, B.; Rüstemoğlu, A. The Effect of Trichostatin A on Radiosensitivity in Glioblastoma. Proceedings 2019, 40, 22.

AMA Style

Taspinar M, Çakir T, Güven M, Denizler FN, Kartal B, Rüstemoğlu A. The Effect of Trichostatin A on Radiosensitivity in Glioblastoma. Proceedings. 2019; 40(1):22.

Chicago/Turabian Style

Taspinar, Mehmet; Çakir, Tahir; Güven, Mustafa; Denizler, Farika Nur; Kartal, Bahar; Rüstemoğlu, Aydin. 2019. "The Effect of Trichostatin A on Radiosensitivity in Glioblastoma" Proceedings 40, no. 1: 22.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop