Oral Granular Cell Tumour: A Case Report †
by
Marta Dani
1,*, 
Maria Pellilli
2,
Alessandro d’Aiuto
1,
Lucia Tettamanti
3,
Vittorio Maurino
3 and
Lorenzo Azzi
1 1
Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi, Dental Clinic, Unit of Oral Medicine and Pathology, 21100 Varese, Italy
2
Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi, Unit of Pathology, 21100 Varese, Italy
3
Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi, Dental Clinic, Unit of Pediatric Dentistry, 21100 Varese, Italy
*
Author to whom correspondence should be addressed.
†
Presented at the XV National and III International Congress of the Italian Society of Oral Pathology and Medicine (SIPMO), Bari, Italy, 17–19 October 2019.
Proceedings 2019, 35(1), 55; https://doi.org/10.3390/proceedings2019035055
Published: 12 December 2019
(This article belongs to the Proceedings of The XV National and III International Congress of the Italian Society of Oral Pathology and Medicine)
1. Case Presentation
A 16-year-old girl presented at our attention with an asymptomatic nodular lesion on the tongue. Clinically, the lesion appeared as a submucosal smooth nodule, 5 mm in diameter, covered by a pink-yellowish looking mucosa (Figure 1). On palpation, it was well defined, but not encapsulated. The lesion was located on the right posterior dorsum of the tongue, it had been slowly growing for a few months, and it was completely asymptomatic. The patient’s anamnesis revealed atopic dermatitis and pityriasis rosea.
Clinically, the lesion was placed in differential diagnosis with other “soft tissue tumors”. Therefore, an excisional biopsy of the lesion was performed with subsequent histopathological analysis.
2. Histopathology
The connective tissue displayed a well-defined proliferation of cells with a characteristic granular cytoplasm. The cells had a characteristic granular eosinophilic cytoplasm positive to PAS staining. The neoplastic cells had a polygonal shape, large dimensions and indefinite margins (Figure 2). The nucleus was roundish and with free chromatin. There was no nuclear atypia and the Ki-67 proliferation index was low. A peculiar histological element of the granular cell tumor was the presence of pseudoepitheliomatous hyperplasia (PEH).
3. Conclusions
Granular cell tumor (GCT) is a benign soft tissue neoplasm. GCT can develop throughout the body but it shows a clear preference for the head-neck district. In particular, in 50% of cases it develops on the tongue, precisely on the lateral margins and back of the tongue [2].
PEH places this lesion in a differential diagnosis with a well-differentiated squamous cell tumor [3]. In order to avoid dangerous diagnostic errors, which can lead to unnecessary lingual mutilation, it is essential to perform a correct biopsy test. Bioptic sampling must include both the epithelial lamina and the lamina propria, where the granular cell tumor develops.
Conflicts of Interest
The authors declare no conflict of interest.
References
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Figure 1.
Clinical aspect of the lesion. A pink-yellowish submucosal nodule was detected on the posterior lateral aspect of the tongue.
Figure 1.
Clinical aspect of the lesion. A pink-yellowish submucosal nodule was detected on the posterior lateral aspect of the tongue.
Figure 2.
(a) Histopathological features of OGCT. The tumour was composed of large polygonal granular cells arranged in a pseudosyncitial pattern. The aspect is typical for GCT. (b) Immunohistochemical analysis revaled the tumour cells be positive for S-100, a marker that confirmed the origin from perineural tissues, like the Schwann cells [1].
Figure 2.
(a) Histopathological features of OGCT. The tumour was composed of large polygonal granular cells arranged in a pseudosyncitial pattern. The aspect is typical for GCT. (b) Immunohistochemical analysis revaled the tumour cells be positive for S-100, a marker that confirmed the origin from perineural tissues, like the Schwann cells [1].
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MDPI and ACS Style
Dani, M.; Pellilli, M.; d’Aiuto, A.; Tettamanti, L.; Maurino, V.; Azzi, L. Oral Granular Cell Tumour: A Case Report. Proceedings 2019, 35, 55. https://doi.org/10.3390/proceedings2019035055
AMA Style
Dani M, Pellilli M, d’Aiuto A, Tettamanti L, Maurino V, Azzi L. Oral Granular Cell Tumour: A Case Report. Proceedings. 2019; 35(1):55. https://doi.org/10.3390/proceedings2019035055
Chicago/Turabian StyleDani, Marta, Maria Pellilli, Alessandro d’Aiuto, Lucia Tettamanti, Vittorio Maurino, and Lorenzo Azzi. 2019. "Oral Granular Cell Tumour: A Case Report" Proceedings 35, no. 1: 55. https://doi.org/10.3390/proceedings2019035055
