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Proceedings 2018, 2(25), 1546; https://doi.org/10.3390/proceedings2251546

The Effect of Pre-Postnatal Nicotine Exposure on Types and Levels of Plasma Sialic Acids in Rats

1
Clinical Biochemistry Laboratory, Usak Training and Research Hospital, Usak 64100, Turkey
2
Department of Biology, Faculty of Science, Ege University, Izmir 35100, Turkey
3
Department of Biotechnology, Institute of Science, Ege University, Izmir 35100, Turkey
4
Department of Medical Biochemistry, Faculty of Medicine, Ege University, Izmir 35100, Turkey
Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018.
*
Author to whom correspondence should be addressed.
Published: 6 December 2018
PDF [468 KB, uploaded 6 December 2018]

Abstract

Nicotine, is an alkaloid compound consisting of pyridine and pyrolidine ring. Its closed formula is C10H4N2. During smoking peak plasma concentration changes from 25 to 50 ng/mL. Its half-life is 1–2 h. Nicotine is metabolized primarily in the liver and excreted by the kidneys. The plasma concentration of the nicotine metabolite cotinine is 10 times more than nicotine and its half-life is longer around 15 to 20 h. Cotinine can be found in both amniotic fluid and umbilical cord blood given that it passes across the placental barrier. Adverse effects of nicotine and its metabolites on the fetus are suggested but have not been proven by scientific explanations till now. Sialic acid (Sia) is a modified nine-carbon sugar. They are located on the last end of the glycan chains located in the glycoconjugate structures. They organize a wide range of relationships between cells and their environment such as cellular recognition, adhesion, transmission, differentiation and aging. The aim of this study is to determine the possible changes in the sialic acid levels and types in the plasma after different levels of nicotine applied to Swiss Albino rats in order to assess the effect of long-term per oral nicotine administration.
Keywords: pre-postnatal; nicotine; sialic acid; LC-MS/MS pre-postnatal; nicotine; sialic acid; LC-MS/MS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mizrak, S.; Sahar, U.; Rashnonejad, A.; Deveci, R.; Ercan, G. The Effect of Pre-Postnatal Nicotine Exposure on Types and Levels of Plasma Sialic Acids in Rats. Proceedings 2018, 2, 1546.

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