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Article

Effect of Cardiac Phase on Cardiac Output Index Derived from Dynamic CT Myocardial Perfusion Imaging

by 1, 2,3,4, 1,2,5 and 1,2,3,*
1
School of Biomedical Engineering, Western University, London, ON N6A 3K7, Canada
2
Department of Medical Biophysics, Western University, London, ON N6A 3K7, Canada
3
Imaging Program, Lawson Health Research Institute, London, ON N6C 2R5, Canada
4
Imaging Research Laboratories, Robarts Research Institute, London, ON N6A 5B7, Canada
5
Department of Electrical and Computer Engineering, Western University, London, ON N6A 3K7, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Emilio Quaia
Tomography 2022, 8(2), 1129-1140; https://doi.org/10.3390/tomography8020092
Received: 9 February 2022 / Revised: 22 March 2022 / Accepted: 31 March 2022 / Published: 14 April 2022
Purpose: The aortic time-enhancement curve obtained from dynamic CT myocardial perfusion imaging can be used to derive the cardiac output (CO) index based on the indicator dilution principle. The objective of this study was to investigate the effect of cardiac phase at which CT myocardial perfusion imaging is triggered on the CO index measurement with this approach. Methods: Electrocardiogram (ECG) gated myocardial perfusion imaging was performed on farm pigs with consecutive cardiac axial scans using a large-coverage CT scanner (Revolution, GE Healthcare) after intravenous contrast administration. Multiple sets of dynamic contrast-enhanced (DCE) cardiac images were reconstructed retrospectively from 30% to 80% R-R intervals with a 5% phase increment. The time-enhancement curve sampled from above the aortic orifice in each DCE image set was fitted with a modified gamma variate function (MGVF). The fitted curve was then normalized to the baseline data point unaffected by the streak artifact emanating from the contrast solution in the right heart chamber. The Stewart–Hamilton equation was used to calculate the CO index based on the integral of the fitted normalized aortic curve, and the results were compared among different cardiac phases. Results: The aortic time-enhancement curves sampled at different cardiac phases were different from each other, especially in the baseline portion of the curve where the effect of streak artifact was prominent. After properly normalizing and denoising with a MGVF, the integrals of the aortic curve were minimally different among cardiac phases (0.228 ± 0.001 Hounsfield Unit × second). The corresponding mean CO index was 4.031 ± 0.028 L/min. There were no statistical differences in either the integral of the aortic curve or CO index among different cardiac phases (p > 0.05 for all phases). View Full-Text
Keywords: cardiac output index; computed tomography; myocardial perfusion imaging; time-enhancement curve cardiac output index; computed tomography; myocardial perfusion imaging; time-enhancement curve
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MDPI and ACS Style

Dempsey, S.C.H.; Lee, T.-Y.; Samani, A.; So, A. Effect of Cardiac Phase on Cardiac Output Index Derived from Dynamic CT Myocardial Perfusion Imaging. Tomography 2022, 8, 1129-1140. https://doi.org/10.3390/tomography8020092

AMA Style

Dempsey SCH, Lee T-Y, Samani A, So A. Effect of Cardiac Phase on Cardiac Output Index Derived from Dynamic CT Myocardial Perfusion Imaging. Tomography. 2022; 8(2):1129-1140. https://doi.org/10.3390/tomography8020092

Chicago/Turabian Style

Dempsey, Sergio C.H., Ting-Yim Lee, Abbas Samani, and Aaron So. 2022. "Effect of Cardiac Phase on Cardiac Output Index Derived from Dynamic CT Myocardial Perfusion Imaging" Tomography 8, no. 2: 1129-1140. https://doi.org/10.3390/tomography8020092

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