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Tomography
Volume 6
Issue 4
10.18383/j.tom.2020.00026
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles

by
Mrudula Pullambhatla
1,
Steven P. Rowe
1,
Ala Lisok
1,
Yuchuan Wang
1,
Gabriele Putz Todd
2,
Alla Danilkovitch
2 and
Martin G. Pomper
1,*
1
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2
Osiris Therapeutics, Columbia, MD, USA
*
Author to whom correspondence should be addressed.
Tomography 2020, 6(4), 373-378; https://doi.org/10.18383/j.tom.2020.00026
Submission received: 10 September 2020 / Revised: 7 October 2020 / Accepted: 5 November 2020 / Published: 1 December 2020
Versions Notes

Abstract

Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xenografts in mice for the purpose of enhancing the effect of radiation therapy. Targeted delivery of GNPs to the tumor site, followed by irradiation of the tumor, enabled control of tumor growth. The results indicate that tumor-selective GNP delivery by human mesenchymal stem cells may represent a viable way to enhance the effectiveness of radiotherapy.
Keywords: MSCs; nanomedicine; targeted delivery; breast cancer; tumor microenvironment; molecular imaging MSCs; nanomedicine; targeted delivery; breast cancer; tumor microenvironment; molecular imaging

Share and Cite

MDPI and ACS Style

Pullambhatla, M.; Rowe, S.P.; Lisok, A.; Wang, Y.; Todd, G.P.; Danilkovitch, A.; Pomper, M.G. Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles. Tomography 2020, 6, 373-378. https://doi.org/10.18383/j.tom.2020.00026

AMA Style

Pullambhatla M, Rowe SP, Lisok A, Wang Y, Todd GP, Danilkovitch A, Pomper MG. Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles. Tomography. 2020; 6(4):373-378. https://doi.org/10.18383/j.tom.2020.00026

Chicago/Turabian Style

Pullambhatla, Mrudula, Steven P. Rowe, Ala Lisok, Yuchuan Wang, Gabriele Putz Todd, Alla Danilkovitch, and Martin G. Pomper. 2020. "Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles" Tomography 6, no. 4: 373-378. https://doi.org/10.18383/j.tom.2020.00026

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