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Clinical Trial Design and Development Work Group Within the Quantitative Imaging Network

School of Medicine, University of California San Francisco, San Francisco, CA, USA
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 1600 Divisadero Street, Box 1667, San Francisco, CA 94115, USA
Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
Winship Cancer Institute, Emory University, Atlanta, GA, USA
School of Medicine, Washington University, St. Louis, MO, USA
Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA
School of Medicine, University of Washington, Seattle, WA, USA
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
School of Medicine, Stanford University, Stanford, CA, USA
Cancer Imaging Program, National Cancer Institute, Bethesda, MD, USA
Department of Radiology, University of Michigan, Ann Arbor, MI, USA
Sidney Kimmel Comprehensive Cancer Center, John Hopkins University, Baltimore, MD, USA
Irving Medical Center, Columbia University, New York Presbyterian Hospital, New York, NY, USA
Author to whom correspondence should be addressed.
Tomography 2020, 6(2), 60-64;
Received: 3 March 2020 / Revised: 3 April 2020 / Accepted: 5 May 2020 / Published: 1 June 2020


The Clinical Trial Design and Development Working Group within the Quantitative Imaging Network focuses on providing support for the development, validation, and harmonization of quantitative imaging (QI) methods and tools for use in cancer clinical trials. In the past 10 years, the Group has been working in several areas to identify challenges and opportunities in clinical trials involving QI and radiation oncology. The Group has been working with Quantitative Imaging Network members and the Quantitative Imaging Biomarkers Alliance leadership to develop guidelines for standardizing the reporting of quantitative imaging. As a validation platform, the Group led a multireader study to test a semi-automated positron emission tomography quantification software. Clinical translation of QI tools cannot be possible without a continuing dialogue with clinical users. This article also highlights the outreach activities extended to cooperative groups and other organizations that promote the use of QI tools to support clinical decisions.
Keywords: Clinical Trial Design and Development (CTDD); Quantitative Imaging Network (QIN) Clinical Trial Design and Development (CTDD); Quantitative Imaging Network (QIN)

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MDPI and ACS Style

Jones, E.F.; Buatti, J.M.; Shu, H.-K.; Wahl, R.L.; Kurland, B.F.; Linden, H.M.; Mankoff, D.A.; Rubin, D.L.; Tata, D.; Nordstrom, R.J.; Hadjiyski, L.; Holdhoff, M.; Schwartz, L.H. Clinical Trial Design and Development Work Group Within the Quantitative Imaging Network. Tomography 2020, 6, 60-64.

AMA Style

Jones EF, Buatti JM, Shu H-K, Wahl RL, Kurland BF, Linden HM, Mankoff DA, Rubin DL, Tata D, Nordstrom RJ, Hadjiyski L, Holdhoff M, Schwartz LH. Clinical Trial Design and Development Work Group Within the Quantitative Imaging Network. Tomography. 2020; 6(2):60-64.

Chicago/Turabian Style

Jones, Ella F., John M. Buatti, Hui-Kuo Shu, Richard L. Wahl, Brenda F. Kurland, Hannah M. Linden, David A. Mankoff, Daniel L. Rubin, Darrell Tata, Robert J. Nordstrom, Lubomir Hadjiyski, Matthias Holdhoff, and Lawrence H. Schwartz. 2020. "Clinical Trial Design and Development Work Group Within the Quantitative Imaging Network" Tomography 6, no. 2: 60-64.

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