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Volume 5
Issue 4
10.18383/j.tom.2019.00018
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Article

Quantification of Human Central Adipose Tissue Depots: An Anatomically Matched Comparison Between DXA and MRI

by
Christopher D. Crabtree
1,
Richard A. LaFountain
1,
Parker N. Hyde
1,
Chong Chen
2,
Yue Pan
3,
Nathan Lamba
2,
Teryn N. Sapper
1,
Jay A. Short
1,
Madison L. Kackley
1,
Alex Buga
1,
Vincent J. Miller
1,
Debbie Scandling
3,
Irma Andersson
4,
Samantha Barker
4,
Houchun H. Hu
5,
Jeff S. Volek
1 and
Orlando P. Simonetti
3,4,6,*
1
Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
2
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA
3
Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
4
Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
5
Department of Radiology, Nationwide Children’s Hospital, Columbus, OH, USA
6
Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(4), 358-366; https://doi.org/10.18383/j.tom.2019.00018
Submission received: 4 June 2019 / Revised: 9 July 2019 / Accepted: 7 August 2019 / Published: 1 December 2019
Versions Notes

Abstract

Excess visceral adipose tissue (VAT) and VAT volume relative to subcutaneous adipose tissue (SAT) are associated with elevated health risks. This study compares fat measurements by dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI). In total, 21 control subjects (Control) and 16 individuals with metabolic syndrome (MetSyn) were scanned by DXA and MRI. The region measured by MRI was matched to the android region defined by DXA, and MRI reproducibility was also evaluated. In addition, liver fat fraction was quantified via MRI and whole-body fat by DXA. VAT measurements are interchangeable between DXA and MRI in the Control (R = 0.946), MetSyn (R = 0.968), and combined cohort (R = 0.983). VAT/SAT ratio did not differ in the Control group (P = .10), but VAT/SAT ratio measured by DXA was significantly higher in the MetSyn group (P < .01) and the combined (P = .03) cohort. Intraobserver (ICC = 0.998) and interobserver (ICC = 0.977) reproducibility of MRI VAT measurements was excellent. Liver fat fraction by MRI was higher (P = .001) in MetSyn (12.4% ± 7.6%) than in controls (2.6% ± 2.2%), as was whole-body fat percentage by DXA (P = .001) between the MetSyn (42.0% ± 8.1%) and Control groups (26.7% ± 6.9%). DXA and MRI VAT are interchangeable when measured over an anatomically matched region of the abdomen, while SAT and VAT/SAT ratio differ between the 2 modalities.
Keywords: MRI; DXA; visceral; adipose; metabolic syndrome MRI; DXA; visceral; adipose; metabolic syndrome

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MDPI and ACS Style

Crabtree, C.D.; LaFountain, R.A.; Hyde, P.N.; Chen, C.; Pan, Y.; Lamba, N.; Sapper, T.N.; Short, J.A.; Kackley, M.L.; Buga, A.; et al. Quantification of Human Central Adipose Tissue Depots: An Anatomically Matched Comparison Between DXA and MRI. Tomography 2019, 5, 358-366. https://doi.org/10.18383/j.tom.2019.00018

AMA Style

Crabtree CD, LaFountain RA, Hyde PN, Chen C, Pan Y, Lamba N, Sapper TN, Short JA, Kackley ML, Buga A, et al. Quantification of Human Central Adipose Tissue Depots: An Anatomically Matched Comparison Between DXA and MRI. Tomography. 2019; 5(4):358-366. https://doi.org/10.18383/j.tom.2019.00018

Chicago/Turabian Style

Crabtree, Christopher D., Richard A. LaFountain, Parker N. Hyde, Chong Chen, Yue Pan, Nathan Lamba, Teryn N. Sapper, Jay A. Short, Madison L. Kackley, Alex Buga, and et al. 2019. "Quantification of Human Central Adipose Tissue Depots: An Anatomically Matched Comparison Between DXA and MRI" Tomography 5, no. 4: 358-366. https://doi.org/10.18383/j.tom.2019.00018

APA Style

Crabtree, C. D., LaFountain, R. A., Hyde, P. N., Chen, C., Pan, Y., Lamba, N., Sapper, T. N., Short, J. A., Kackley, M. L., Buga, A., Miller, V. J., Scandling, D., Andersson, I., Barker, S., Hu, H. H., Volek, J. S., & Simonetti, O. P. (2019). Quantification of Human Central Adipose Tissue Depots: An Anatomically Matched Comparison Between DXA and MRI. Tomography, 5(4), 358-366. https://doi.org/10.18383/j.tom.2019.00018

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