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Article

Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers

1
The First Affiliated Hospital of Kunming Medical University, Kunming 650000, China
2
Chinese Medicine College of Yun Nan, Kunming 650000, China
3
Public Health School of Kunming Medical University, Kunming 650000, China
*
Author to whom correspondence should be addressed.
Tomography 2018, 4(2), 78-83; https://doi.org/10.18383/j.tom.2018.00008
Submission received: 2 March 2018 / Revised: 3 April 2018 / Accepted: 4 May 2018 / Published: 1 June 2018

Abstract

Here, we investigated the diagnostic performance of manganese (Mn)-enhanced magnetic resonance imaging (MEMRI) in colorectal cancer (CRC). The ability of CRC cell lines SW620 and SW480 to uptake Mn was evaluated and compared with a normal colon cell using MEMRI. Subcutaneous xenografts in nude mice underwent MRI examination at tumor sizes of 5, 10, and 15 mm. Contrast enhancement was compared between gadolinium (Gd)- and Mn-enhanced MRI. SW620 and SW480 cell lines took up more Mn2+ than normal cells, resulting in 4.5 and 2 times greater T1 value shortening than normal cell using in vitro MEMRI (P < 0.001). Most xenografts (17/23) enhanced markedly on MEMRI. A heterogeneous enhancement pattern invariably noted whether Mn or Gd agents were administered, but tumors imaged using MEMRI showed a greater degree of enhancement with a larger extent of enhanced area than those imaged using Gd-enhanced MRI. The numbers of markedly Mn-enhanced cases were more in the 5-mm-size tumor group than in 10- or 15-mm-size tumor groups. Overall, MEMRI could enhance CRCs and it showed potential in detecting early small lesions and markedly enhancing tumors that had minimal Gd enhancement.
Keywords: magnetic resonance imaging; manganese-enhanced; colorectal cancer; detection; characterization magnetic resonance imaging; manganese-enhanced; colorectal cancer; detection; characterization

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MDPI and ACS Style

Wen, L.; Shi, X.; He, L.; Han, D. Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers. Tomography 2018, 4, 78-83. https://doi.org/10.18383/j.tom.2018.00008

AMA Style

Wen L, Shi X, He L, Han D. Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers. Tomography. 2018; 4(2):78-83. https://doi.org/10.18383/j.tom.2018.00008

Chicago/Turabian Style

Wen, Liang, Xinan Shi, Liping He, and Dan Han. 2018. "Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers" Tomography 4, no. 2: 78-83. https://doi.org/10.18383/j.tom.2018.00008

APA Style

Wen, L., Shi, X., He, L., & Han, D. (2018). Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers. Tomography, 4(2), 78-83. https://doi.org/10.18383/j.tom.2018.00008

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