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Tomography
Volume 4
Issue 1
10.18383/j.tom.2017.00021
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography

by
Inbal E. Biton
1,
Noa Stettner
1,2,3,
Ori Brener
1,
Ayelet Erez
2,
Alon Harmelin
1 and
Joel R. Garbow
4,*
1
Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel
2
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
3
Koret School of Veterinary Medicine, Hebrew University, Rehovot, Israe
4
Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, WashingtonUniversity, St. Louis, MO, USA
*
Author to whom correspondence should be addressed.
Tomography 2018, 4(1), 4-13; https://doi.org/10.18383/j.tom.2017.00021
Submission received: 6 December 2017 / Revised: 9 January 2018 / Accepted: 6 February 2018 / Published: 1 March 2018
Versions Notes

Abstract

Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate–induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations.
Keywords: magnetic resonance imaging; MR colonography; T2 map; inflammatory bowel disease; ulcerative colitis magnetic resonance imaging; MR colonography; T2 map; inflammatory bowel disease; ulcerative colitis

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MDPI and ACS Style

Biton, I.E.; Stettner, N.; Brener, O.; Erez, A.; Harmelin, A.; Garbow, J.R. Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography. Tomography 2018, 4, 4-13. https://doi.org/10.18383/j.tom.2017.00021

AMA Style

Biton IE, Stettner N, Brener O, Erez A, Harmelin A, Garbow JR. Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography. Tomography. 2018; 4(1):4-13. https://doi.org/10.18383/j.tom.2017.00021

Chicago/Turabian Style

Biton, Inbal E., Noa Stettner, Ori Brener, Ayelet Erez, Alon Harmelin, and Joel R. Garbow. 2018. "Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography" Tomography 4, no. 1: 4-13. https://doi.org/10.18383/j.tom.2017.00021

APA Style

Biton, I. E., Stettner, N., Brener, O., Erez, A., Harmelin, A., & Garbow, J. R. (2018). Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography. Tomography, 4(1), 4-13. https://doi.org/10.18383/j.tom.2017.00021

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