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Tomography
Volume 2
Issue 2
10.18383/j.tom.2016.00139
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER

by
Adam Berrington
1,
Natalie L. Voets
1,
Puneet Plaha
2,
Sarah J. Larkin
3,
James Mccullagh
4,
Richard Stacey
2,
Muhammed Yildirim
5,
Christopher J. Schofield
4,
Peter Jezzard
1,
Tom Cadoux-Hudson
2,
Olaf Ansorge
3 and
Uzay E. Emir
1,*
1
Nuffield Department of Clinical Neurosciences, FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK
2
Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK
3
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
4
Department of Chemistry, University of Oxford, Oxford, UK
5
Advanced Diagnostic Imaging, Philips Healthcare, The Netherlands
*
Author to whom correspondence should be addressed.
Tomography 2016, 2(2), 94-105; https://doi.org/10.18383/j.tom.2016.00139
Submission received: 5 May 2016 / Revised: 9 May 2016 / Accepted: 9 May 2016 / Published: 1 June 2016
Versions Notes

Abstract

2-hydroxyglutarate (2-HG) has emerged as a biomarker of tumor cell isocitrate dehydrogenase mutations that may enable the differential diagnosis of patients with glioma. At 3 T, detection of 2-HG with magnetic resonance spectroscopy is challenging because of metabolite signal overlap and spectral pattern modulation by slice selection and chemical shift displacement. Using density matrix simulations and phantom experiments, an optimized semi-LASER scheme (echo time = 110 milliseconds) considerably improves localization of the 2-HG spin system compared with that of an existing point-resolved spectroscopy sequence. This results in a visible 2-HG peak in the in vivo spectra at 1.9 ppm in the majority of isocitrate dehydrogenase-mutated tumors. Detected concentrations of 2-HG were similar using both sequences, although the use of semi-LASER generated narrower confidence intervals. Signal overlap with glutamate and glutamine, as measured by pairwise fitting correlation, was reduced. Lactate was readily detectable across patients with glioma using the method presented here (mean Cramér–Rao lower bound: 10% ± 2%). Together with more robust 2-HG detection, long-echo time semi-LASER offers the potential to investigate tumor metabolism and stratify patients in vivo at 3 T.
Keywords: 2-HG; semi-LASER; MRS; glioma 2-HG; semi-LASER; MRS; glioma

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MDPI and ACS Style

Berrington, A.; Voets, N.L.; Plaha, P.; Larkin, S.J.; Mccullagh, J.; Stacey, R.; Yildirim, M.; Schofield, C.J.; Jezzard, P.; Cadoux-Hudson, T.; et al. Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER. Tomography 2016, 2, 94-105. https://doi.org/10.18383/j.tom.2016.00139

AMA Style

Berrington A, Voets NL, Plaha P, Larkin SJ, Mccullagh J, Stacey R, Yildirim M, Schofield CJ, Jezzard P, Cadoux-Hudson T, et al. Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER. Tomography. 2016; 2(2):94-105. https://doi.org/10.18383/j.tom.2016.00139

Chicago/Turabian Style

Berrington, Adam, Natalie L. Voets, Puneet Plaha, Sarah J. Larkin, James Mccullagh, Richard Stacey, Muhammed Yildirim, Christopher J. Schofield, Peter Jezzard, Tom Cadoux-Hudson, and et al. 2016. "Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER" Tomography 2, no. 2: 94-105. https://doi.org/10.18383/j.tom.2016.00139

APA Style

Berrington, A., Voets, N. L., Plaha, P., Larkin, S. J., Mccullagh, J., Stacey, R., Yildirim, M., Schofield, C. J., Jezzard, P., Cadoux-Hudson, T., Ansorge, O., & Emir, U. E. (2016). Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER. Tomography, 2(2), 94-105. https://doi.org/10.18383/j.tom.2016.00139

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