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Article

Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study

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Azpilagaña Health Center, Navarra Health Service, 31006 Pamplona, Navarra, Spain
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Department of Health Sciences, Public University of Navarra (UPNA), 31008 Pamplona, Navarra, Spain
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Department of Nursing, Clinica Universidad de Navarra, 31008 Pamplona, Navarra, Spain
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Department of Psychiatry, Clinica Universidad de Navarra, 31008 Pamplona, Navarra, Spain
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Navarra Institute of Health Research (IdiSNA), 31008 Pamplona, Navarra, Spain
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Department of Preventive Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Navarra, Spain
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CIBER-OBN, Instituto de Salud Carlos III, 28029 Madrid, Comunidad de Madrid, Spain
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Department of Endocrinology, University Hospital of Navarra, C/Irunlarrea s/n, 31008 Pamplona, Navarra, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Paolo Emilio Puddu
J. Cardiovasc. Dev. Dis. 2022, 9(1), 25; https://doi.org/10.3390/jcdd9010025
Received: 28 December 2021 / Revised: 5 January 2022 / Accepted: 11 January 2022 / Published: 13 January 2022
(This article belongs to the Section Epidemiology, Lifestyle, and Cardiovascular Health)
(1) Background: Patients with schizophrenia have higher mortality, with cardiovascular diseases being the first cause of mortality. This study aims to estimate the excess risk of hospital admission for cardiovascular events in schizophrenic patients, adjusting for comorbidity and risk factors. (2) Methods: The APNA study is a dynamic prospective cohort of all residents in Navarra, Spain. A total of 505,889 people over 18 years old were followed for five years. The endpoint was hospital admissions for a cardiovascular event. Direct Acyclic Graphs (DAG) and Cox regression were used. (3) Results: Schizophrenic patients had a Hazard Ratio (HR) of 1.414 (95% CI 1.031–1.938) of hospital admission for a cardiovascular event after adjusting for age, sex, hypertension, type 2 diabetes, dyslipidemia, smoking, low income, obesity, antecedents of cardiovascular disease, and smoking. In non-adherent to antipsychotic treatment schizophrenia patients, the HR was 2.232 (95% CI 1.267–3.933). (4) Conclusions: Patients with schizophrenia have a higher risk of hospital admission for cardiovascular events than persons with the same risk factors without schizophrenia. Primary care nursing interventions should monitor these patients and reduce cardiovascular risk factors. View Full-Text
Keywords: cardiovascular; schizophrenia; prospective cohort; hospital admissions cardiovascular; schizophrenia; prospective cohort; hospital admissions
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MDPI and ACS Style

Guillen-Aguinaga, S.; Brugos-Larumbe, A.; Guillen-Aguinaga, L.; Ortuño, F.; Guillen-Grima, F.; Forga, L.; Aguinaga-Ontoso, I. Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study. J. Cardiovasc. Dev. Dis. 2022, 9, 25. https://doi.org/10.3390/jcdd9010025

AMA Style

Guillen-Aguinaga S, Brugos-Larumbe A, Guillen-Aguinaga L, Ortuño F, Guillen-Grima F, Forga L, Aguinaga-Ontoso I. Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study. Journal of Cardiovascular Development and Disease. 2022; 9(1):25. https://doi.org/10.3390/jcdd9010025

Chicago/Turabian Style

Guillen-Aguinaga, Sara, Antonio Brugos-Larumbe, Laura Guillen-Aguinaga, Felipe Ortuño, Francisco Guillen-Grima, Luis Forga, and Ines Aguinaga-Ontoso. 2022. "Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study" Journal of Cardiovascular Development and Disease 9, no. 1: 25. https://doi.org/10.3390/jcdd9010025

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