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J. Cardiovasc. Dev. Dis. 2018, 5(3), 47; https://doi.org/10.3390/jcdd5030047

Postprandial Hypertriglyceridemia Is Associated with the Variant 54 Threonine FABP2 Gene

1
Associated Research Laboratorio de Investigaciones Básicas y Aplicadas, Departamento de Bioquímica, Escuela de Bioanálisis, Facultad de Medicina, Universidad Central de Venezuela, Caracas 48321, Venezuela
2
National Academy of Medicine, Caracas 41421, Venezuela
3
Laboratorio de Fisiopatología, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas 21827, Venezuela
4
Associated Research Clinical Chemistry Laboratory, Department Laboratory Medicine, Karolinska Institute, 14186 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Received: 26 August 2018 / Revised: 10 September 2018 / Accepted: 10 September 2018 / Published: 13 September 2018
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Abstract

Purpose: Fasting or postprandial hypertriglyceridemia is considered an independent cardiovascular disease (CVD) risk factor. The intestinal fatty acid binding protein (FABP2) is involved in the intracellular transport and metabolism of fatty acids. The presence of the Ala54Thr polymorphism of the FABP2 gene appears to be involved in postprandial hypertriglyceridemia. We explored the possible association of the Ala54Thr polymorphism with fat intolerance in apparently healthy, fasting, normolipidemic subjects with normal body-mass index and without diabetes. Methodology: A total of 158 apparently healthy individuals were classified as fat tolerant (n = 123) or intolerant (n = 35) according to their response (plasma triglycerides) to an oral abbreviated tolerance test with blood samples taken at 0, 2 and 4 h. At 0 h, all subjects ingested 26.3 g of fats. Presence of the Ala54Thr polymorphism of the FABP2 gene was evaluated by polymerase chain reaction–restriction fragment length (PCR–RFLP). Results: The group with fat intolerance (postprandial hypertriglyceridemia group) showed an increased frequency of the Thr54Thr genotype when compared with the group with normal fat tolerance (control group) (23% vs. 4%, respectively, OR: 16.53, 95% CI: 4.09–66.82, p: 0.0001, pc: 0.0003). Carriers of at least one Thr54 allele were up to six times more prevalent in the fat intolerant group than in the non-carriers. (OR: 6.35; 95% CI: 1.86–21.59, p: 0.0003, pc: 0.0009). The levels of plasma triglycerides (Tg) at 4 h after the test meal were higher in carriers of at least one 54Thr allele than in carriers of the Ala54 allele (p < 0.05). Conclusions: There is a significant association between postprandial hypertriglyceridemia and the presence of at least one 54Thr allele of the FABP2 gene. In addition, subjects with this genotype showed an increased ratio of Tg/HDL-cholesterol. This parameter is a marker of increased CVD risk and insulin resistance. View Full-Text
Keywords: FABP2 gene polymorphism; oral fat tolerance test; normolipidemic non-obese healthy subjects; hypertriglyceridemia FABP2 gene polymorphism; oral fat tolerance test; normolipidemic non-obese healthy subjects; hypertriglyceridemia
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Garcés Da Silva, M.F.; Guarin, Y.A.; Carrero, Y.; Stekman, H.; Núñez Bello, M.L.; Hernández, C.; Apitz, R.; Fernández-Mestre, M.; Camejo, G. Postprandial Hypertriglyceridemia Is Associated with the Variant 54 Threonine FABP2 Gene. J. Cardiovasc. Dev. Dis. 2018, 5, 47.

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