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Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years

1
The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, D02 R590 Dublin, Ireland
2
Falls and Syncope Unit, Mercer’s Institute for Successful Ageing, St James’s Hospital, D08 NHY1 Dublin, Ireland
3
Global Brain Health Institute, Trinity College Dublin, D02 PN40 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Catherine M. Roe
Geriatrics 2021, 6(2), 50; https://doi.org/10.3390/geriatrics6020050
Received: 8 April 2021 / Revised: 5 May 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
Previous research cross-sectionally characterised eight morphological systolic blood pressure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the Irish Longitudinal Study on Ageing. We explored the longitudinal stability and clinical associations of these groupings at Wave 3 (W3), four years later. Eight AS groups had their clinical characteristics and AS patterns at W3 compared to W1. We explored longitudinal associations (new cognitive decline, falls, syncope, disability, and mortality) using multivariate logistic regression models. In total, 2938 participants (60% of Wave 1 sample) had adequate AS data from both W1 and 3 for analysis. We found no longitudinal stability of the eight AS groups or their morphological patterns between the waves. A pattern of impaired stabilisation and late deficit seemed more preserved and was seen in association with new cognitive decline (OR 1.63, 95% CI: 1.12–2.36, p = 0.011). An increase in antihypertensive usage seemed associated with reduced immediate SBP drops, improved AS patterns, and reduced orthostatic intolerance (OI). In pure longitudinal groups, AS patterns were not preserved after 4 years. AS patterns are longitudinally dynamic, and improvements after 4 years are possible even in the presence of higher antihypertensive burden. View Full-Text
Keywords: orthostatic hypotension; falls; syncope; longitudinal; physiological monitoring orthostatic hypotension; falls; syncope; longitudinal; physiological monitoring
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MDPI and ACS Style

Moloney, D.; Knight, S.P.; Newman, L.; Kenny, R.A.; Romero-Ortuno, R. Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years. Geriatrics 2021, 6, 50. https://doi.org/10.3390/geriatrics6020050

AMA Style

Moloney D, Knight SP, Newman L, Kenny RA, Romero-Ortuno R. Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years. Geriatrics. 2021; 6(2):50. https://doi.org/10.3390/geriatrics6020050

Chicago/Turabian Style

Moloney, David, Silvin P. Knight, Louise Newman, Rose Anne Kenny, and Roman Romero-Ortuno. 2021. "Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years" Geriatrics 6, no. 2: 50. https://doi.org/10.3390/geriatrics6020050

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