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Is a Combination of Melatonin and Amino Acids Useful to Sarcopenic Elderly Patients? A Randomized Trial

1
IRCCS Mondino Foundation, 27100 Pavia, Italy
2
Department of Public Health, Experimental and Forensic Medicine, Unit of Human and Clinical Nutrition, University of Pavia, 27100 Pavia, Italy
3
Department of Biomedical Science and Human Oncology, University of Bari, 70121 Bari, Italy
4
A.S.P.S. Margherita Geriatric Department, 27100 Pavia, Italy
5
Department of Biology, College of Science, University of Bahrain, Sakhir Campus P.O. Box 32038, Kingdom of Bahrain
*
Author to whom correspondence should be addressed.
Geriatrics 2019, 4(1), 4; https://doi.org/10.3390/geriatrics4010004
Received: 15 November 2018 / Revised: 12 December 2018 / Accepted: 21 December 2018 / Published: 24 December 2018
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Abstract

This study evaluated the effectiveness of a 4-week intervention of melatonin and essential aminoacid supplementation on body composition, protein metabolism, strength and inflammation in 159 elderly sarcopenic patients (42/117, men/women), assigned to four groups: isocaloric placebo (P, n = 44), melatonin (M, 1 mg/daily, n = 42), essential amino acids (eAA 4 g/daily, n = 40) or eAA plus melatonin (eAAM, 4 g eAA and 1 mg melatonin/daily, n = 30). Data from body composition (dual X-ray absortiometry (DXA)), strength (handgrip test) and biochemical parameters for the assessment of protein metabolism (albumin) and inflammation (CRP) were collected at baseline and after the 4-week intervention. Compared with P and M, supplementation with eAA plus M increased total fat-free mass (vs. P: +2190 g; p < 0.01; vs. M: +2107 g; p < 0.05). M alone lowered albumin levels (vs. P: −0.39 g; p < 0.01; vs. eAA: −0.47 g; p < 0.01). This data on albumin was confirmed by within-group analysis (M −0.44g; p < 0.001; eAAM: −0.34 p < 0.05). M and eAA seemed to lower the percentage of gynoid fat (p < 0.05) and android fat (p < 0.01). No significant changes in inflammation or strength were reported. A 4-week intervention with eAA plus M together may be effective in enhancing fat-free-mass compared to M and P but not versus eAA. M alone demonstrates a negative effect on albumin level. View Full-Text
Keywords: melatonin; sarcopenia; muscle mass; inflammation; antioxidants melatonin; sarcopenia; muscle mass; inflammation; antioxidants
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Rondanelli, M.; Peroni, G.; Gasparri, C.; Infantino, V.; Nichetti, M.; Cuzzoni, G.; Spadaccini, D.; Perna, S. Is a Combination of Melatonin and Amino Acids Useful to Sarcopenic Elderly Patients? A Randomized Trial. Geriatrics 2019, 4, 4.

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