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The Management of Older Adults with Pancreatic Adenocarcinoma

1
Division of Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905 USA
2
Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Geriatrics 2018, 3(4), 85; https://doi.org/10.3390/geriatrics3040085
Received: 19 September 2018 / Revised: 9 November 2018 / Accepted: 23 November 2018 / Published: 26 November 2018
(This article belongs to the Special Issue Oncology Care and Research in the Elderly)
Pancreatic cancer is the eleventh most common cancer, yet it is the third leading cause of mortality. It is also largely a disease of older adults, with the median age of 71 at diagnosis in the US, with <1% of diagnoses occurring prior to age 50. Current NCCN guidelines recommend surgery for localized disease, followed by adjuvant therapy and/or consideration of enrollment in a clinical trial. For metastatic disease, current guidelines recommend clinical trial enrollment or systemic chemotherapy based on results from the landmark ACCORD-11 and MPACT trials. However, these trials focused heavily on younger, more fit patients, with the ACCORD-11 trial excluding patients over age 75 and the MPACT trial having 92% of its patients with a Karnofsky performance score >80. This article summarizes the available evidence in current literature in regards to the best treatment options for older adults, who represent the majority of pancreatic cancer diagnoses. View Full-Text
Keywords: pancreatic adenocarcinoma; older adults; disease management; localized disease; metastatic disease pancreatic adenocarcinoma; older adults; disease management; localized disease; metastatic disease
MDPI and ACS Style

Ogden, J.R.; Xie, H.; Ma, W.W.; Hubbard, J.M. The Management of Older Adults with Pancreatic Adenocarcinoma. Geriatrics 2018, 3, 85. https://doi.org/10.3390/geriatrics3040085

AMA Style

Ogden JR, Xie H, Ma WW, Hubbard JM. The Management of Older Adults with Pancreatic Adenocarcinoma. Geriatrics. 2018; 3(4):85. https://doi.org/10.3390/geriatrics3040085

Chicago/Turabian Style

Ogden, John R., Hao Xie, Wen Wee Ma, and Joleen M. Hubbard. 2018. "The Management of Older Adults with Pancreatic Adenocarcinoma" Geriatrics 3, no. 4: 85. https://doi.org/10.3390/geriatrics3040085

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