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Geriatrics 2016, 1(4), 33;

Call to Caution with the Use of Atypical Antipsychotics for Treatment of Depression in Older Adults

Department of Neurology, University of Rochester, Rochester, NY 14642, USA
Author to whom correspondence should be addressed.
Academic Editor: Robert C. Abrams
Received: 11 August 2016 / Revised: 12 December 2016 / Accepted: 14 December 2016 / Published: 16 December 2016
(This article belongs to the Special Issue Depressive Disorder in the Elderly)
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Atypical antipsychotics are increasingly being used to manage depression in older adults where these symptoms can often be refractory to first-line treatment with selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs). Unfortunately, atypical antipsychotics can be associated with the development of extrapyramidal symptoms (EPS), with drug-induced parkinsonism (DIP) being the most common movement disorder induced by this class of medication. The management of treatment-resistant depression in older adults is of particular concern as depression is a common feature of idiopathic Parkinson’s disease (IPD) and can manifest prior to the development of motor symptoms. Herein, we discuss the use of atypical antipsychotics for the management of depression in older adults including the risk of DIP and propose that antipsychotics may potentially unmask IPD. View Full-Text
Keywords: antipsychotic; SNRIs; SSRIs; depression; IPD; DIP; neuroleptic antipsychotic; SNRIs; SSRIs; depression; IPD; DIP; neuroleptic

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Amodeo, K.; Schneider, R.B.; Hegeman Richard, I. Call to Caution with the Use of Atypical Antipsychotics for Treatment of Depression in Older Adults. Geriatrics 2016, 1, 33.

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