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Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes

1
Department of Biochemistry, Ahmadu Bello University, Zaria 811104, Nigeria
2
Directorate of Research and Development, Nigerian Institute of Leather and science Technology, Zaria 810221, Nigeria
*
Author to whom correspondence should be addressed.
Academic Editor: Basil Roufogalis
Medicines 2017, 4(4), 73; https://doi.org/10.3390/medicines4040073
Received: 16 August 2017 / Revised: 27 September 2017 / Accepted: 5 October 2017 / Published: 11 October 2017
Background: Ocimum gratissimum (OG) is used in the traditional management of diabetes in Nigeria. This study investigated the anti-diabetic potential of OG leaf fractions (OGLF) in a rat model of Type-2 diabetes (T2D). Method: Methanol crude extract of OG leaf was fractionated with solvents of increasing order of polarity (n-hexane, chloroform, ethyl-acetate, n-butanol and water). The anti-diabetic potential of the fractions was evaluated in vivo. T2D was induced in Albino Wistar rats and treated with OGLF. Result: The T2D rats showed significant elevation in serum levels of fasting blood glucose (FBG), liver and kidney function biomarkers. At 4-weeks of intervention with OGLF, the untreated diabetic control group maintained severe hyperglycaemia in the presence of 61.7% serum insulin, 17.3% pancreatic β-cell function (HOMA-β) and 51.5% Insulin sensitivity. The glucose tolerance ability was enhanced in the n-butanol-fraction (OGb) treated group. With 74.8% available serum insulin and 38.6% improvement in insulin sensitivity, the OGb treated group had a 63.5% reduction in FBG and it was found to be most effective as it ameliorates a majority of the changes caused in the studied parameters in diabetic rats. Conclusions: The data from this study suggest that OGb fraction is a potential candidate for the development of an effective drug for the management of T2D. View Full-Text
Keywords: Type-2 diabetes; Ocimum gratissimum; hyperglycaemia; hyperlipidaemia; rats Type-2 diabetes; Ocimum gratissimum; hyperglycaemia; hyperlipidaemia; rats
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MDPI and ACS Style

Okoduwa, S.I.R.; Umar, I.A.; James, D.B.; Inuwa, H.M. Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes. Medicines 2017, 4, 73. https://doi.org/10.3390/medicines4040073

AMA Style

Okoduwa SIR, Umar IA, James DB, Inuwa HM. Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes. Medicines. 2017; 4(4):73. https://doi.org/10.3390/medicines4040073

Chicago/Turabian Style

Okoduwa, Stanley I.R.; Umar, Isamila A.; James, Dorcas B.; Inuwa, Hajiya M. 2017. "Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes" Medicines 4, no. 4: 73. https://doi.org/10.3390/medicines4040073

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