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Dent. J. 2018, 6(2), 20;

Bacterial Colonization and Tissue Compatibility of Denture Base Resins

Department of Prosthodontics and Material Science, University of Leipzig, 04103 Leipzig, Germany
Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, 04107 Leipzig, Germany
Section of Oral Medicine, Department of Head Medicine and Oral Health, University of Leipzig, 04103 Leipzig, Germany
Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University Hospital of Leipzig, 04103 Leipzig, Germany
Author to whom correspondence should be addressed.
Received: 18 May 2018 / Revised: 8 June 2018 / Accepted: 12 June 2018 / Published: 15 June 2018
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Currently, there is minimal clinical data regarding biofilm composition on the surface of denture bases and the clinical tissue compatibility. Therefore, the aim of this experimental study was to compare the bacterial colonization and the tissue compatibility of a hypoallergenic polyamide with a frequently used PMMA resin tested intraorally in a randomized split-mouth design. Test specimens made of polyamide (n = 10) and PMMA (n = 10) were attached over a molar band appliance in oral cavity of 10 subjects. A cytological smear test was done from palatal mucosa at baseline and after four weeks. The monolayers were inspected for micronuclei. After four weeks in situ, the appliance was removed. The test specimens were immediately cultivated on non-selective and selective nutrient media. All growing colonies were identified using VITEK-MS. The anonymized results were analyzed descriptively. A total of 110 different bacterial species could be isolated, including putative pathogens. An average of 17.8 different bacterial species grew on the PMMA specimens, and 17.3 on the polyamide specimens. The highest number of different bacterial species was n = 24, found on a PMMA specimen. On the two specimens, a similar bacterial distribution was observed. Micronuclei, as a marker for genotoxic potential of dental materials, were not detected. This study indicates that the composition of bacterial biofilm developed on these resins after four weeks is not influenced by the type of resin itself. The two materials showed no cytological differences. This investigation suggests that polyamide and PMMA are suitable for clinical use as denture base material. View Full-Text
Keywords: bacteria; polymethyl methacrylate; polyamide; cell biology bacteria; polymethyl methacrylate; polyamide; cell biology

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Olms, C.; Yahiaoui-Doktor, M.; Remmerbach, T.W.; Stingu, C.S. Bacterial Colonization and Tissue Compatibility of Denture Base Resins. Dent. J. 2018, 6, 20.

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