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GERMS
Volume 7
Issue 2
10.18683/germs.2017.1110
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Article

Enterococcus spp. and S. aureus Colonization in NEUTROPENIC Febrile Children with Cancer

by
Julia R. Spinardi
,
Rodrigo Berea
,
Patricia A. Orioli
,
Marina M. Gabriele
,
Alessandra Navarini
,
Marina T. Marques
,
Milton N. Neto
and
Marcelo J. Mimica
*
Department of Pathology (Division of Microbiology), Santa Casa de São Paulo School of Medicine, Rua Dr Cesario Mota Junior 61, Vila Buarque—CEP: 01221-020, São Paulo, SP, Brazil
*
Author to whom correspondence should be addressed.
GERMS 2017, 7(2), 61-72; https://doi.org/10.18683/germs.2017.1110
Submission received: 8 November 2016 / Revised: 26 February 2017 / Accepted: 18 April 2017 / Published: 1 June 2017
Versions Notes

Abstract

Introduction: Febrile neutropenia is one of the most serious treatment-related complications in cancer patients. Susceptible to rapidly progressing infections, which result in prolonged hospitalization and use of broad-spectrum antibiotics, neutropenic patients are subject to colonization by multiresistant agents, which enhances the risk of infections. Methods: In this study we included samples collected with nasal, oropharyngeal and anal swabs from hospitalized children with febrile neutropenia following chemotherapy, between March 2014 and 2015, aiming to elucidate colonization by S. aureus and Enterococcus spp., as well as their resistance profile. Results: S. aureus was found in 22% of the patients and 14% of the events. Methicillin-resistant S. aureus colonized 13.6% of patients. Including anal swabs in the screening increased the identification of colonized patients by 20%. Enterococcus spp. was found in 27% of patients and 17% of episodes. Enterococcal isolates resistant to vancomycin, accounting for 25% of the total, were not isolated in anal swabs at any time, with the oropharyngeal site being much more important. The rate of infection by Enterococcus spp. was 4.5% of all patients and 16% among the colonized patients. Conclusion: Especially in this population, colonization studies including more sites can yield a higher chance of positive results. Establishing the colonization profile in febrile neutropenic children following chemotherapy may help to institute an empirical antibiotic treatment aimed at antibiotic adequacy and lower induction of resistance, thereby decreasing the risk of an unfavorable clinical outcome.
Keywords: Enterococcus; enterocolitis; neutropenic; fever; pediatrics; Staphylococcus aureus Enterococcus; enterocolitis; neutropenic; fever; pediatrics; Staphylococcus aureus

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MDPI and ACS Style

Spinardi, J.R.; Berea, R.; Orioli, P.A.; Gabriele, M.M.; Navarini, A.; Marques, M.T.; Neto, M.N.; Mimica, M.J. Enterococcus spp. and S. aureus Colonization in NEUTROPENIC Febrile Children with Cancer. GERMS 2017, 7, 61-72. https://doi.org/10.18683/germs.2017.1110

AMA Style

Spinardi JR, Berea R, Orioli PA, Gabriele MM, Navarini A, Marques MT, Neto MN, Mimica MJ. Enterococcus spp. and S. aureus Colonization in NEUTROPENIC Febrile Children with Cancer. GERMS. 2017; 7(2):61-72. https://doi.org/10.18683/germs.2017.1110

Chicago/Turabian Style

Spinardi, Julia R., Rodrigo Berea, Patricia A. Orioli, Marina M. Gabriele, Alessandra Navarini, Marina T. Marques, Milton N. Neto, and Marcelo J. Mimica. 2017. "Enterococcus spp. and S. aureus Colonization in NEUTROPENIC Febrile Children with Cancer" GERMS 7, no. 2: 61-72. https://doi.org/10.18683/germs.2017.1110

APA Style

Spinardi, J. R., Berea, R., Orioli, P. A., Gabriele, M. M., Navarini, A., Marques, M. T., Neto, M. N., & Mimica, M. J. (2017). Enterococcus spp. and S. aureus Colonization in NEUTROPENIC Febrile Children with Cancer. GERMS, 7(2), 61-72. https://doi.org/10.18683/germs.2017.1110

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