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Volume 5
Issue 2
10.11599/germs.2015.1069
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

Vancomycin Minimum Inhibitory Concentrations and Lethality in Staphylococcus aureus Bacteremia

by
Felipe Sulla
,
Daniel T. Bussius
,
Felipe Acquesta
,
Alessandra Navarini
,
Suzethe M. Sasagawa
and
Marcelo J. Mimica
Division of Microbiology, Department of Pathology, Santa Casa School of Medicine, São Paulo, Brazil
GERMS 2015, 5(2), 39-43; https://doi.org/10.11599/germs.2015.1069
Submission received: 10 February 2015 / Revised: 17 April 2015 / Accepted: 2 May 2015 / Published: 1 June 2015
Versions Notes

Abstract

Background: After the dissemination of penicillin and oxacillin resistance in Staphylococcus aureus, vancomycin-intermediate and vancomycin resistant isolates have been reported. Even between isolates with minimum inhibitory concentrations (MICs) within the susceptible range, some authors have demonstrated that higher MICs correlate with higher lethality. Methods: To test this hypothesis in our setting, we compared vancomycin MICs evaluated by two methods and clinical outcomes in hospitalized patients with S. aureus bacteremia. Results: We compared lethality in patients infected with isolates that had MICs under or over 2 mg/L. Among patients infected with isolates that had microdilution MICs <2 mg/L, the lethality was 25%; among patients infected with strains that had microdilution MICs ≥2 mg/L, 33% died. Among patients infected with isolates that had Etest MICs <2 mg/L, 23% died; in comparison, patients infected with strains that had Etest MICs ≥2 mg/L had a lethality of 44%. Conclusion: Our results showed a slight tendency of higher lethality when higher MICs were present. However, this difference did not reach statistical significance, possibly due to the relatively small number of patients included in the study. Future prospective studies are needed to further evaluate this correlation and to help clinicians guide antimicrobial therapy.
Keywords: S. aureus; vancomycin; susceptibility S. aureus; vancomycin; susceptibility

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MDPI and ACS Style

Sulla, F.; Bussius, D.T.; Acquesta, F.; Navarini, A.; Sasagawa, S.M.; Mimica, M.J. Vancomycin Minimum Inhibitory Concentrations and Lethality in Staphylococcus aureus Bacteremia. GERMS 2015, 5, 39-43. https://doi.org/10.11599/germs.2015.1069

AMA Style

Sulla F, Bussius DT, Acquesta F, Navarini A, Sasagawa SM, Mimica MJ. Vancomycin Minimum Inhibitory Concentrations and Lethality in Staphylococcus aureus Bacteremia. GERMS. 2015; 5(2):39-43. https://doi.org/10.11599/germs.2015.1069

Chicago/Turabian Style

Sulla, Felipe, Daniel T. Bussius, Felipe Acquesta, Alessandra Navarini, Suzethe M. Sasagawa, and Marcelo J. Mimica. 2015. "Vancomycin Minimum Inhibitory Concentrations and Lethality in Staphylococcus aureus Bacteremia" GERMS 5, no. 2: 39-43. https://doi.org/10.11599/germs.2015.1069

APA Style

Sulla, F., Bussius, D. T., Acquesta, F., Navarini, A., Sasagawa, S. M., & Mimica, M. J. (2015). Vancomycin Minimum Inhibitory Concentrations and Lethality in Staphylococcus aureus Bacteremia. GERMS, 5(2), 39-43. https://doi.org/10.11599/germs.2015.1069

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