Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India

Rai, Amit K; Tilak, Ragini; Tiwari, Punit; Meena, Pooja; Kumar, Ashok; Tiwari, Atul K; Gupta, Munesh K

doi:10.18683/germs.2024.1414

Open AccessArticle

Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India

by

Amit K Rai

^1,2,

Ragini Tilak

²,

Punit Tiwari

²,

Pooja Meena

²,

Ashok Kumar

²,

Atul K Tiwari

³ and

Munesh K Gupta

^2,*

¹

Department of Microbiology, AIIMS Gorakhpur, Uttar Pradesh, India

²

Department of Microbiology, IMS BHU Varanasi, Uttar Pradesh, India

³

Department of Chemistry, Indian Institute of Technology, BHU Varanasi, Uttar Pradesh, India

^*

Author to whom correspondence should be addressed.

GERMS 2024, 14(1), 20-27; https://doi.org/10.18683/germs.2024.1414

Submission received: 30 December 2023 / Revised: 7 February 2024 / Accepted: 10 February 2024 / Published: 31 March 2024

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Abstract

Introduction: Neonatal candidemia is a life-threatening event in babies requiring ICU admission. Prompt diagnosis and appropriate treatment reduce mortality and morbidity. Worldwide, there is an emergence of drug-resistant rare Candida species causing neonatal sepsis that necessitates antifungal susceptibility testing in each case. Methods: We did a prospective study to isolate Candida species causing neonatal sepsis and to determine the predisposing risk factors and time to positivity for flagged positivity. We also determined fluconazole, itraconazole and amphotericin B minimum inhibitory concentration (MIC) against isolated Candida species by broth microdilution method using CLSI M27-A3 guidelines. Results: A total of 107 neonatal candidemia events were noted. Prematurity was the most common predisposing risk factor. Most isolates were non-albicans Candida. Candida utilis, C. pelliculosa, C. tropicalis and K. ohmeri were the predominant fungi causing neonatal candidemia. A varied antifungal MIC against isolated Candida species was noted. However, 90% of the isolated Candida strains had <8 µg/mL fluconazole MIC. Moreover, ≥8 and ≥2 µg/mL MIC for fluconazole and amphotericin B respectively were also noted. Conclusions: Rare Candida species having varied fluconazole and amphotericin B MIC cause neonatal candidemia. Therefore, culture isolation and antifungal susceptibility testing should be done in each case of neonatal candidemia.

Keywords: fluconazole; amphotericin B; Candida auris; neonatal sepsis; Candida utilis; C. pelliculosa

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MDPI and ACS Style

Rai, A.K.; Tilak, R.; Tiwari, P.; Meena, P.; Kumar, A.; Tiwari, A.K.; Gupta, M.K. Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India. GERMS 2024, 14, 20-27. https://doi.org/10.18683/germs.2024.1414

AMA Style

Rai AK, Tilak R, Tiwari P, Meena P, Kumar A, Tiwari AK, Gupta MK. Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India. GERMS. 2024; 14(1):20-27. https://doi.org/10.18683/germs.2024.1414

Chicago/Turabian Style

Rai, Amit K, Ragini Tilak, Punit Tiwari, Pooja Meena, Ashok Kumar, Atul K Tiwari, and Munesh K Gupta. 2024. "Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India" GERMS 14, no. 1: 20-27. https://doi.org/10.18683/germs.2024.1414

APA Style

Rai, A. K., Tilak, R., Tiwari, P., Meena, P., Kumar, A., Tiwari, A. K., & Gupta, M. K. (2024). Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India. GERMS, 14(1), 20-27. https://doi.org/10.18683/germs.2024.1414

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Emergence of Rare and Uncommon Yeast-like Pathogens Causing Neonatal Sepsis at a Tertiary Care Center, North India

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