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Volume 13
Issue 1
10.18683/germs.2023.1370
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Case Report

A Rare Presentation of Infectious Mononucleosis: Cholestatic Hepatitis with Hyperbilirubinemia

by
Aldin Jerome
1,
Vatsal Khanna
1,
Elisa Akagi
2 and
Ashish Bhargava
3,*
1
Department of Medicine, Wayne State University SOM/Ascension Providence Rochester Hospital, 1101 W. University Dr, Rochester, MI 48307, USA
2
Department of Medicine, Ascension St. John Hospital, 22101 Moross Rd, Grosse Pointe Woods, MI 48236, USA
3
Department of Medicine, Thomas Mackey Center for Infectious Disease Research, Ascension St. John Hospital, 22101 Moross Rd, Grosse Pointe Woods, MI 48236, USA
*
Author to whom correspondence should be addressed.
GERMS 2023, 13(1), 80-85; https://doi.org/10.18683/germs.2023.1370
Submission received: 12 June 2022 / Revised: 30 January 2022 / Accepted: 19 February 2023 / Published: 31 March 2023
Versions Notes

Abstract

Introduction Epstein-Barr virus infection with mononucleosis is the most common presentation in young adults. Most infections are self-limited, although in a few cases complications can include serious conditions such as lymphoproliferative disorders or in less severe cases, mild hepatitis. Case report We present an unusual case of a young male with no liver disease, who presented with markedly elevated cholestatic pattern hyperbilirubinemia, as well as hepatitis. The patient responded well to symptomatic treatments, with spontaneous improvement of the hyperbilirubinemia and transaminitis. Conclusions Epstein-Barr virus mononucleosis can frequently present with mild elevation of transaminases, but very rarely can have marked elevation of bilirubin, which may make clinicians doubt that the infection is the sole culprit of the process.
Keywords: infectious mononucleosis; EBV; cholestasis; hepatitis infectious mononucleosis; EBV; cholestasis; hepatitis

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MDPI and ACS Style

Jerome, A.; Khanna, V.; Akagi, E.; Bhargava, A. A Rare Presentation of Infectious Mononucleosis: Cholestatic Hepatitis with Hyperbilirubinemia. GERMS 2023, 13, 80-85. https://doi.org/10.18683/germs.2023.1370

AMA Style

Jerome A, Khanna V, Akagi E, Bhargava A. A Rare Presentation of Infectious Mononucleosis: Cholestatic Hepatitis with Hyperbilirubinemia. GERMS. 2023; 13(1):80-85. https://doi.org/10.18683/germs.2023.1370

Chicago/Turabian Style

Jerome, Aldin, Vatsal Khanna, Elisa Akagi, and Ashish Bhargava. 2023. "A Rare Presentation of Infectious Mononucleosis: Cholestatic Hepatitis with Hyperbilirubinemia" GERMS 13, no. 1: 80-85. https://doi.org/10.18683/germs.2023.1370

APA Style

Jerome, A., Khanna, V., Akagi, E., & Bhargava, A. (2023). A Rare Presentation of Infectious Mononucleosis: Cholestatic Hepatitis with Hyperbilirubinemia. GERMS, 13(1), 80-85. https://doi.org/10.18683/germs.2023.1370

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