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GERMS
Volume 12
Issue 4
10.18683/germs.2022.1351
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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

The Mycological Efficacy and Safety of Selenium Sulfide 1.8% Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: A Double-Blind Randomized Controlled Trial

by
Lusiana
1,*,
Lis Surachmiati
1,
Siti Rizny Fitriana Saldi
2,
Trah Lusianingtyas
3 and
Kusmarinah Bramono
1
1
Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta 10430, Indonesia
2
Center for Clinical Epidemiology and Evidence-based Medicine (CEEBM), Dr. Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia
3
Public Health Center (Pusat Kesehatan Masyarakat) Pulo Gadung, Jakarta 13260, Indonesia
*
Author to whom correspondence should be addressed.
GERMS 2022, 12(4), 452-460; https://doi.org/10.18683/germs.2022.1351
Submission received: 4 May 2022 / Revised: 13 October 2022 / Accepted: 31 December 2022 / Published: 31 December 2022
Versions Notes

Abstract

Introduction: Although it has long been used as a topical treatment of pityriasis versicolor (PV), the efficacy of topical selenium disulfide as compared to topical ketoconazole in the treatment of PV remains unclear. This study aims to assess the mycological efficacy and safety of SeS2 1.8% shampoo and ketoconazole 2% shampoo for the treatment of PV. Methods: A double-blind randomized controlled trial was performed in patients with PV during September–December 2018, based on block randomization. Physical examinations, scale provocation test, Wood’s lamp, and potassium hydroxide examination were conducted. Intention to treat analysis was performed to evaluate the mycological efficacy. Results: The mycological efficacy and side effect were not significantly different between the ketoconazole group and the selenium group; 94% vs. 86% (RR = 2.3(95%CI 0.6–8.5), p = 0.182), and 22% versus 8%. Conclusions: SeS2 1.8% has the same mycological efficacy and side effect as compared to ketoconazole 2% in the treatment of PV.
Keywords: ketoconazole 2%; mycological efficacy; pityriasis versicolor; selenium sulfide 1.8% ketoconazole 2%; mycological efficacy; pityriasis versicolor; selenium sulfide 1.8%

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MDPI and ACS Style

Lusiana; Surachmiati, L.; Saldi, S.R.F.; Lusianingtyas, T.; Bramono, K. The Mycological Efficacy and Safety of Selenium Sulfide 1.8% Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: A Double-Blind Randomized Controlled Trial. GERMS 2022, 12, 452-460. https://doi.org/10.18683/germs.2022.1351

AMA Style

Lusiana, Surachmiati L, Saldi SRF, Lusianingtyas T, Bramono K. The Mycological Efficacy and Safety of Selenium Sulfide 1.8% Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: A Double-Blind Randomized Controlled Trial. GERMS. 2022; 12(4):452-460. https://doi.org/10.18683/germs.2022.1351

Chicago/Turabian Style

Lusiana, Lis Surachmiati, Siti Rizny Fitriana Saldi, Trah Lusianingtyas, and Kusmarinah Bramono. 2022. "The Mycological Efficacy and Safety of Selenium Sulfide 1.8% Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: A Double-Blind Randomized Controlled Trial" GERMS 12, no. 4: 452-460. https://doi.org/10.18683/germs.2022.1351

APA Style

Lusiana, Surachmiati, L., Saldi, S. R. F., Lusianingtyas, T., & Bramono, K. (2022). The Mycological Efficacy and Safety of Selenium Sulfide 1.8% Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: A Double-Blind Randomized Controlled Trial. GERMS, 12(4), 452-460. https://doi.org/10.18683/germs.2022.1351

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