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Volume 11
Issue 2
10.18683/germs.2021.1256
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Article

Update on the Resistance of Escherichia coli Isolated from Urine Specimens in a Moroccan Hospital: A Review of a 7-Year Period

by
Elmostafa Benaissa
1,*,
Nadia Elmrimar
1,
Elmehdi Belouad
1,
Youness Mechal
2,
Mohammed Ghazouani
2,
Fatna Bsaibiss
2,
Yassine Benlahlou
1,
Mariama Chadli
2,
Nadia Touil
3,
Abdelhay Lemnaouer
1,
Adil Maleb
4 and
Mostafa Elouennass
1
1
Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Avenue Mohamed Belarbi El Alaoui, Rabat B.P. 6203, Morocco
2
Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Avenue Mohamed Belarbi El Alaoui, Rabat B.P. 6203, Morocco
3
Research and Biosafety Laboratory, Mohammed V Military Teaching Hospital/Faculty of Medicine and Pharmacy, Mohammed V University, Avenue Mohamed Belarbi El Alaoui, Rabat B.P. 6203, Morocco
4
Department of Clinical Bacteriology, Mohammed VI Hospital, Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Avenue Mohamed Belarbi El Alaoui, Rabat B.P. 6203, Morocco
*
Author to whom correspondence should be addressed.
GERMS 2021, 11(2), 189-198; https://doi.org/10.18683/germs.2021.1256
Submission received: 30 December 2020 / Revised: 10 April 2021 / Accepted: 19 April 2021 / Published: 2 June 2021
Versions Notes

Abstract

Introduction: Escherichia coli is the most commonly isolated species in both community and healthcare-associated infections. Our study's purpose was to determine the rates of antibiotic resistance of E. coli isolates in hospital and community populations, track the kinetics of resistance rates of E. coli isolates to major antibiotics, particularly those prescribed for urinary tract infections and study the occurrence and evolution of multi-resistant phenotypes. Methods: We conducted a retrospective study at the Bacteriological Department of the Mohammed V Military Hospital of Instruction, over a period of 7 years. All isolates of E. coli from inpatients and outpatients were included. Identification of bacterial isolates was based on culture, morphological and biochemical identification characteristics. Antibiotic susceptibility was studied using the Mueller Hilton agar diffusion method by using OXOID® type antibiotic discs and interpreted according to the recommendations of EUCAST/CA-SFM 2019. Results: The rate of resistance of E. coli isolates to 3rd generation cephalosporins, imipenem and fluoroquinolones was 12%, 1% and 34%, respectively. The difference between the resistance rates of inpatient and outpatient E. coli isolates was statistically significant for most antibiotics (p<0.05). The rate of extended-spectrum beta-lactamase phenotype (ESBL) was 6.73%. The carbapenemase phenotype was 1.25%. The ESBL phenotype rate increased from 3% in 2012 to 11.16% in 2018. Conclusions: The progression of the ESBL phenotype in both hospital and community settings, due to the increase in the resistance rate to 3rd generation cephalosporin, is prompting a review of the strategy for the therapeutic management of urinary tract infections with these molecules as probabilistic treatment.
Keywords: Escherichia coli; resistance; ESBL; carbapenemase; phenotype Escherichia coli; resistance; ESBL; carbapenemase; phenotype

Share and Cite

MDPI and ACS Style

Benaissa, E.; Elmrimar, N.; Belouad, E.; Mechal, Y.; Ghazouani, M.; Bsaibiss, F.; Benlahlou, Y.; Chadli, M.; Touil, N.; Lemnaouer, A.; et al. Update on the Resistance of Escherichia coli Isolated from Urine Specimens in a Moroccan Hospital: A Review of a 7-Year Period. GERMS 2021, 11, 189-198. https://doi.org/10.18683/germs.2021.1256

AMA Style

Benaissa E, Elmrimar N, Belouad E, Mechal Y, Ghazouani M, Bsaibiss F, Benlahlou Y, Chadli M, Touil N, Lemnaouer A, et al. Update on the Resistance of Escherichia coli Isolated from Urine Specimens in a Moroccan Hospital: A Review of a 7-Year Period. GERMS. 2021; 11(2):189-198. https://doi.org/10.18683/germs.2021.1256

Chicago/Turabian Style

Benaissa, Elmostafa, Nadia Elmrimar, Elmehdi Belouad, Youness Mechal, Mohammed Ghazouani, Fatna Bsaibiss, Yassine Benlahlou, Mariama Chadli, Nadia Touil, Abdelhay Lemnaouer, and et al. 2021. "Update on the Resistance of Escherichia coli Isolated from Urine Specimens in a Moroccan Hospital: A Review of a 7-Year Period" GERMS 11, no. 2: 189-198. https://doi.org/10.18683/germs.2021.1256

APA Style

Benaissa, E., Elmrimar, N., Belouad, E., Mechal, Y., Ghazouani, M., Bsaibiss, F., Benlahlou, Y., Chadli, M., Touil, N., Lemnaouer, A., Maleb, A., & Elouennass, M. (2021). Update on the Resistance of Escherichia coli Isolated from Urine Specimens in a Moroccan Hospital: A Review of a 7-Year Period. GERMS, 11(2), 189-198. https://doi.org/10.18683/germs.2021.1256

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