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Article

Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes

1
Center for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia
2
108 Military Central Hospital, Ha Noi 11517, Vietnam
*
Author to whom correspondence should be addressed.
Academic Editor: Marie Černá
Biomedicines 2021, 9(9), 1260; https://doi.org/10.3390/biomedicines9091260
Received: 12 August 2021 / Revised: 8 September 2021 / Accepted: 14 September 2021 / Published: 18 September 2021
(This article belongs to the Section Molecular and Translational Medicine)
Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control the survival, proliferation, differentiation, and effector function of immune cells. All components of the TNF superfamily are associated with NF-kB functions that are not limited to cell death and may promote survival in the face of adipose tissue inflammation in obesity. Inflammation dysfunction of mitochondria is a key factor associated with insulin resistance in obesity. The aim of the study was to analyze the relationship of soluble forms of receptors and ligands of the TNF superfamily in blood plasma with mitochondrial dynamics in adipose tissue (greater omentum (GO) and subcutaneous adipose tissue (Sat)) of obese patients with and without type 2 diabetes mellitus (T2DM). Increased plasma sTNF-R1, sTNF-R2, sTNFRSF8 receptors, and ligands TNFSF12, TNFSF13, TNFSF13B are characteristic of obese patients without T2DM. The TNF-a levels in blood plasma were associated with a decrease in MFN2 gene expression in GO and IL-10 in blood plasma. The TNFSF12 levels contributed to a decrease in glucose levels, a decrease in BMI, and an increase in IL-10 levels by influencing the MFN2 gene expression in GO, which supports mitochondrial fusion. View Full-Text
Keywords: NF-kB; non-canonical NF-κB pathway; sTNFR2; sTNFRSF8; sTNFSF13; mitochondrial dynamics; fission and fusion; TFAM NF-kB; non-canonical NF-κB pathway; sTNFR2; sTNFRSF8; sTNFSF13; mitochondrial dynamics; fission and fusion; TFAM
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MDPI and ACS Style

Shunkina, D.; Komar, A.; Vulf, M.; Quang, H.V.; Shunkin, E.; Kirienkova, E.; Dakchnevich, A.; Malkov, D.; Zatolokin, P.; Litvinova, L. Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes. Biomedicines 2021, 9, 1260. https://doi.org/10.3390/biomedicines9091260

AMA Style

Shunkina D, Komar A, Vulf M, Quang HV, Shunkin E, Kirienkova E, Dakchnevich A, Malkov D, Zatolokin P, Litvinova L. Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes. Biomedicines. 2021; 9(9):1260. https://doi.org/10.3390/biomedicines9091260

Chicago/Turabian Style

Shunkina, Daria, Alexandra Komar, Maria Vulf, Hung V. Quang, Egor Shunkin, Elena Kirienkova, Anastasiia Dakchnevich, Danil Malkov, Pavel Zatolokin, and Larisa Litvinova. 2021. "Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes" Biomedicines 9, no. 9: 1260. https://doi.org/10.3390/biomedicines9091260

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