Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals and Treatments
2.2. Femoral Artery Ligation and Tissue Processing
2.3. Histology and Immunohistology
2.4. Cell Culture
2.5. Quantitative Real-Time PCR (qRT-PCR)
2.6. Statistical Analyses
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Carmeliet, P. Angiogenesis in health and disease. Nat. Med. 2003, 9, 653–660. [Google Scholar] [CrossRef]
- Jain, R.K. Molecular regulation of vessel maturation. Nat. Med. 2003, 9, 685–693. [Google Scholar] [CrossRef]
- Tonnesen, M.G.; Feng, X.; Clark, R.A. Angiogenesis in wound healing. J. Investig. Dermatol. Symp. Proc. 2000, 5, 40–46. [Google Scholar] [CrossRef]
- Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1995, 1, 27–30. [Google Scholar] [CrossRef]
- Priya, S.K.; Nagare, R.P.; Sneha, V.; Sidhanth, C.; Bindhya, S.; Manasa, P.; Ganesan, T. Tumour angiogenesis—Origin of blood vessels. Int. J. Cancer 2016, 139, 729–735. [Google Scholar] [CrossRef]
- Yu, J.; Ba, J.; Peng, R.-S.; Xu, D.; Li, Y.-H.; Shi, H.; Wang, Q. Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: A systematic review and meta-analysis. Drug Des. Dev. Ther. 2015, 9, 5397–5405. [Google Scholar] [CrossRef]
- Garcia, J.; Hurwitz, H.I.; Sandler, A.B.; Miles, D.; Coleman, R.L.; Deurloo, R.; Chinot, O.L. Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook. Cancer Treat. Rev. 2020, 86, 102017. [Google Scholar] [CrossRef] [PubMed]
- Elshabrawy, H.A.; Chen, Z.; Volin, M.V.; Ravella, S.; Virupannavar, S.; Shahrara, S. The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis 2015, 18, 433–448. [Google Scholar] [CrossRef] [PubMed]
- DiPietro, L.A. Angiogenesis and wound repair: When enough is enough. J. Leukoc. Biol. 2016, 100, 979–984. [Google Scholar] [CrossRef] [PubMed]
- Emanueli, C.; Madeddu, P. Angiogenesis gene therapy to rescue ischaemic tissues: Achievements and future directions. Br. J. Pharmacol. 2001, 133, 951–958. [Google Scholar] [CrossRef]
- Badimon, L.; Borrell, M. Microvasculature recovery by angiogenesis after myocardial infarction. Curr. Pharm. Des. 2018, 24, 2967–2973. [Google Scholar] [CrossRef]
- Inampudi, C.; Akintoye, E.; Ando, T.; Briasoulis, A. Angiogenesis in peripheral arterial disease. Curr. Opin. Pharmacol. 2018, 39, 60–67. [Google Scholar] [CrossRef] [PubMed]
- Ruan, L.; Wang, B.; ZhuGe, Q.; Jin, K. Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Res. 2015, 1623, 166–173. [Google Scholar] [CrossRef] [PubMed]
- Deindl, E.; Schaper, W. The art of arteriogenesis. Cell Biophys. 2005, 43, 1–15. [Google Scholar] [CrossRef]
- Faber, J.E.; Chilian, W.M.; Deindl, E.; Van Royen, N.; Simons, M. A brief etymology of the collateral circulation. Arter. Thromb. Vasc. Biol. 2014, 34, 1854–1859. [Google Scholar] [CrossRef] [PubMed]
- Heil, M.; Eitenmüller, I.; Schmitz-Rixen, T.; Schaper, W. Arteriogenesis versus angiogenesis: Similarities and differences. J. Cell. Mol. Med. 2006, 10, 45–55. [Google Scholar] [CrossRef]
- Rizzi, A.; Benagiano, V.; Ribatti, D. Angiogenesis versus arteriogenesis. Rom. J. Morphol. Embryol 2017, 58, 15–19. [Google Scholar] [PubMed]
- Adams, R.H.; Alitalo, K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 2007, 8, 464–478. [Google Scholar] [CrossRef]
- Egginton, S.; Zhou, A.-L.; Brown, M.D.; Hudlická, O. Unorthodox angiogenesis in skeletal muscle. Cardiovasc. Res. 2001, 49, 634–646. [Google Scholar] [CrossRef]
- Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 2000, 6, 389–395. [Google Scholar] [CrossRef] [PubMed]
- Mentzer, S.J.; Konerding, M.A. Intussusceptive angiogenesis: Expansion and remodeling of microvascular networks. Angiogenesis 2014, 17, 499–509. [Google Scholar] [CrossRef]
- Risau, W. Mechanisms of angiogenesis. Nat. Cell Biol. 1997, 386, 671–674. [Google Scholar] [CrossRef]
- Demir, R.; Yaba, A.; Huppertz, B. Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation. Acta Histochem. 2010, 112, 203–214. [Google Scholar] [CrossRef]
- Karizbodagh, M.P.; Rashidi, B.; Sahebkar, A.; Masoudifar, A.; Mirzaei, H. Implantation window and angiogenesis. J. Cell. Biochem. 2017, 118, 4141–4151. [Google Scholar] [CrossRef]
- Hudlicka, O.; Brown, M.; Egginton, S. Angiogenesis in skeletal and cardiac muscle. Physiol. Rev. 1992, 72, 369–417. [Google Scholar] [CrossRef]
- Weckbach, L.T.; Preissner, K.T.; Deindl, E. The role of midkine in arteriogenesis, involving mechanosensing, endothelial cell proliferation, and vasodilation. Int. J. Mol. Sci. 2018, 19, 2559. [Google Scholar] [CrossRef] [PubMed]
- Gerhardt, H.; Golding, M.; Fruttiger, M.; Ruhrberg, C.; Lundkvist, A.; Abramsson, A.; Jeltsch, M.; Mitchell, C.; Alitalo, K.; Shima, D.; et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 2003, 161, 1163–1177. [Google Scholar] [CrossRef] [PubMed]
- Ferrara, N.; Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 1989, 161, 851–858. [Google Scholar] [CrossRef]
- Ferrara, N.; Gerber, H.-P.; LeCouter, J. The biology of VEGF and its receptors. Nat. Med. 2003, 9, 669–676. [Google Scholar] [CrossRef] [PubMed]
- Schwarz, E.R.; Speakman, M.T.; Patterson, M.; Hale, S.S.; Isner, J.M.; Kedes, L.H.; A Kloner, R. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat—Angiogenesis and angioma formation. J. Am. Coll. Cardiol. 2000, 35, 1323–1330. [Google Scholar] [CrossRef]
- Scapini, P.; Morini, M.; Tecchio, C.; Minghelli, S.; Di Carlo, E.; Tanghetti, E.; Albini, A.; Lowell, C.; Berton, G.; Noonan, D.M.; et al. CXCL1/Macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J. Immunol. 2004, 172, 5034–5040. [Google Scholar] [CrossRef]
- Gaudry, M.; Brégerie, O.; Andrieu, V.; El Benna, J.; A Pocidalo, M.; Hakim, J. Intracellular pool of vascular endothelial growth factor in human neutrophils. Blood 1997, 90, 4153–4161. [Google Scholar] [CrossRef]
- Scapini, P.; Calzetti, F.; A Cassatella, M. On the detection of neutrophil-derived vascular endothelial growth factor (VEGF). J. Immunol. Methods 1999, 232, 121–129. [Google Scholar] [CrossRef]
- Stockmann, C.; Kirmse, S.; Helfrich, I.; Weidemann, A.; Takeda, N.; Doedens, A.; Johnson, R.S. A Wound size–dependent effect of myeloid cell–derived vascular endothelial growth factor on wound healing. J. Investig. Dermatol. 2011, 131, 797–801. [Google Scholar] [CrossRef] [PubMed]
- Nissen, N.N.; Polverini, P.J.; Koch, A.E.; Volin, M.V.; Gamelli, R.L.; DiPietro, L.A. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am. J. Pathol. 1998, 152, 1445–1452. [Google Scholar] [PubMed]
- Berse, B.; Brown, L.F.; Van De Water, L.; Dvorak, H.F.; Senger, D.R. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 1992, 3, 211–220. [Google Scholar] [CrossRef]
- Brinkmann, V.; Reichard, U.; Goosmann, C.; Fauler, B.; Uhlemann, Y.; Weiss, D.S.; Weinrauch, Y.; Zychlinsky, A. Neutrophil extracellular traps kill bacteria. Science 2004, 303, 1532–1535. [Google Scholar] [CrossRef]
- Rohrbach, A.S.; Slade, D.J.; Thompson, P.R.; Mowen, K.A. Activation of PAD4 in NET formation. Front. Immunol. 2012, 3, 360. [Google Scholar] [CrossRef]
- Zawrotniak, M.; Rapala-Kozik, M. Neutrophil extracellular traps (NETs) - formation and implications. Acta Biochim. Pol. 2013, 60, 277–284. [Google Scholar] [CrossRef]
- Aldabbous, L.; Abdul-Salam, V.; McKinnon, T.; Duluc, L.; Pepke-Zaba, J.; Southwood, M.; Ainscough, A.J.; Hadinnapola, C.; Wilkins, M.R.; Toshner, M.; et al. Neutrophil extracellular traps promote angiogenesis: Evidence from vascular pathology in pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 2016, 36, 2078–2087. [Google Scholar] [CrossRef]
- Binet, F.; Cagnone, G.; Crespo-Garcia, S.; Hata, M.; Neault, M.; Dejda, A.; Wilson, A.M.; Buscarlet, M.; Mawambo, G.T.; Howard, J.P.; et al. Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science 2020, 369, 5356. [Google Scholar] [CrossRef] [PubMed]
- Lefrançais, E.; Mallavia, B.; Zhuo, H.; Calfee, C.S.; Looney, M.R. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI Insight 2018, 3. [Google Scholar] [CrossRef] [PubMed]
- Wong, S.L.; Demers, M.; Martinod, K.; Gallant, M.; Wang, Y.; Goldfine, A.B.; Kahn, C.R.; Wagner, D.D. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat. Med. 2015, 21, 815–819. [Google Scholar] [CrossRef]
- Saffarzadeh, M.; Juenemann, C.; Queisser, M.A.; Lochnit, G.; Barreto, G.; Galuska, S.P.; Lohmeyer, J.; Preissner, K.T. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: A predominant role of histones. PLoS ONE 2012, 7, e32366. [Google Scholar] [CrossRef]
- Gerstberger, S.; Hafner, M.; Tuschl, T. A census of human RNA-binding proteins. Nat. Rev. Genet. 2014, 15, 829–845. [Google Scholar] [CrossRef]
- Lukong, K.E.; Chang, K.-W.; Khandjian, E.W.; Richard, S. RNA-binding proteins in human genetic disease. Trends Genet. 2008, 24, 416–425. [Google Scholar] [CrossRef] [PubMed]
- Chang, S.-H.; Hla, T. Gene regulation by RNA binding proteins and microRNAs in angiogenesis. Trends Mol. Med. 2011, 17, 650–658. [Google Scholar] [CrossRef]
- Nishiyama, H.; Itoh, K.; Kaneko, Y.; Kishishita, M.; Yoshida, O.; Fujita, J. A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. J. Cell Biol. 1997, 137, 899–908. [Google Scholar] [CrossRef]
- Zhong, P.; Huang, H. Recent progress in the research of cold-inducible RNA-binding protein. Future Sci. OA 2017, 3, FSO246. [Google Scholar] [CrossRef]
- De Leeuw, F.; Zhang, T.; Wauquier, C.; Huez, G.; Kruys, V.; Gueydan, C. The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Exp. Cell Res. 2007, 313, 4130–4144. [Google Scholar] [CrossRef]
- Yang, R.; Zhan, M.; Nalabothula, N.R.; Yang, Q.; Indig, F.E.; Carrier, F. Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3′-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript. J. Biol. Chem. 2010, 285, 8887–8893. [Google Scholar] [CrossRef]
- Chen, X.; Liu, X.; Li, B.; Zhang, Q.; Wang, J.; Zhang, W.; Luo, W.; Chen, J. Cold inducible RNA binding protein is involved in chronic hypoxia induced neuron apoptosis by down-regulating HIF-1α expression and regulated by microRNA-23a. Int. J. Biol. Sci. 2017, 13, 518–531. [Google Scholar] [CrossRef] [PubMed]
- Sumitomo, Y.; Higashitsuji, H.; Higashitsuji, H.; Liu, Y.; Fujita, T.; Sakurai, T.; Candeias, M.M.; Itoh, K.; Chiba, T.; Fujita, J. Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells. BMC Biotechnol. 2012, 12, 72. [Google Scholar] [CrossRef] [PubMed]
- Yang, R.; Weber, D.J.; Carrier, F. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. Nucleic Acids Res. 2006, 34, 1224–1236. [Google Scholar] [CrossRef] [PubMed]
- Zhang, Y.; Wu, Y.; Mao, P.; Li, F.; Han, X.; Zhang, Y.; Jiang, S.; Chen, Y.; Huang, J.; Liu, D.; et al. Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner. Nucleic Acids Res. 2016, 44, 761–775. [Google Scholar] [CrossRef]
- Na Lee, H.; Ahn, S.-M.; Jang, H.H. Cold-inducible RNA-binding protein, CIRP, inhibits DNA damage-induced apoptosis by regulating p53. Biochem. Biophys. Res. Commun. 2015, 464, 916–921. [Google Scholar] [CrossRef] [PubMed]
- Sakurai, T.; Itoh, K.; Higashitsuji, H.; Nonoguchi, K.; Liu, Y.; Watanabe, H.; Nakano, T.; Fukumoto, M.; Chiba, T.; Fujita, J. Cirp protects against tumor necrosis factor-α-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim. Biophys. Acta 2006, 1763, 290–295. [Google Scholar] [CrossRef]
- Chang, E.T.; Parekh, P.R.; Yang, Q.; Nguyen, D.M.; Carrier, F. Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells. Oncotarget 2016, 7, 10578–10593. [Google Scholar] [CrossRef] [PubMed]
- Zhang, D.; Lv, F.-L.; Wang, G.-H. Effects of HIF-1α on diabetic retinopathy angiogenesis and VEGF expression. Eur. Rev. Med. Pharmacol. Sci. 2018, 22, 5071–5076. [Google Scholar]
- Gerstberger, S.; Hafner, M.; Ascano, M.; Tuschl, T. Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease. Adv. Exp. Med. Biol. 2014, 825, 1–55. [Google Scholar]
- Xia, Z.; Zheng, X.; Zheng, H.; Liu, X.; Yang, Z.; Wang, X. Cold-inducible RNA-binding protein (CIRP) regulates target mRNA stabilization in the mouse testis. FEBS Lett. 2012, 586, 3299–3308. [Google Scholar] [CrossRef] [PubMed]
- Coburn, K.; Melville, Z.; Aligholizadeh, E.; Roth, B.M.; Varney, K.M.; Carrier, F.; Pozharski, E.; Weber, D.J. Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif. Acta Crystallogr. Sect. F Struct. Biol. Commun. 2017, 73, 209–214. [Google Scholar] [CrossRef] [PubMed]
- Guo, X.; Wu, Y.; Hartley, R.S. Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer. Mol. Carcinog. 2009, 49, 130–140. [Google Scholar] [CrossRef]
- Lujan, D.A.; Ochoa, J.L.; Hartley, R.S. Cold-inducible RNA binding protein in cancer and inflammation. Wiley Interdiscip. Rev. RNA 2018, 9, e1462. [Google Scholar] [CrossRef] [PubMed]
- Aziz, M.; Brenner, M.; Wang, P. Extracellular CIRP (eCIRP) and inflammation. J. Leukoc. Biol. 2019, 106, 133–146. [Google Scholar] [CrossRef]
- Qiang, X.; Yang, W.-L.; Wu, R.; Zhou, M.; Jacob, A.; Dong, W.; Kuncewitch, M.; Ji, Y.; Yang, H.; Wang, H.; et al. Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat. Med. 2013, 19, 1489–1495. [Google Scholar] [CrossRef]
- Takizawa, S.; Murao, A.; Ochani, M.; Aziz, M.; Wang, P. Frontline science: Extracellular CIRP generates a proinflammatory Ly6G + CD11b hi subset of low-density neutrophils in sepsis. J. Leukoc. Biol. 2020. [Google Scholar] [CrossRef]
- Ode, Y.; Aziz, M.; Jin, H.; Arif, A.; Nicastro, J.G.; Wang, P. Cold-inducible RNA-binding protein induces neutrophil extracellular traps in the lungs during sepsis. Sci. Rep. 2019, 9, 1–11. [Google Scholar] [CrossRef] [PubMed]
- Ode, Y.; Aziz, M.; Wang, P. CIRP increases ICAM-1 + phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis. J. Leukoc. Biol. 2018, 103, 693–707. [Google Scholar] [CrossRef]
- Murao, A.; Arif, A.; Brenner, M.; Denning, N.-L.; Jin, H.; Takizawa, S.; Nicastro, B.; Wang, P.; Aziz, M. Extracellular CIRP and TREM-1 axis promotes ICAM-1-Rho-mediated NETosis in sepsis. FASEB J. 2020, 34, 9771–9786. [Google Scholar] [CrossRef]
- Welten, S.M.; Bastiaansen, A.J.; De Jong, R.C.; De Vries, M.R.; Peters, E.A.; Boonstra, M.C.; Sheikh, S.P.; La Monica, N.; Kandimalla, E.R.; Quax, P.H.; et al. Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia. Circ. Res. 2014, 115, 696–708. [Google Scholar] [CrossRef] [PubMed]
- Velasco, A.D.R.; Welten, S.M.; Goossens, E.A.; Quax, P.H.; Rappsilber, J.; Michlewski, G.; Nossent, A.Y. Posttranscriptional regulation of 14q32 MicroRNAs by the CIRBP and HADHB during vascular regeneration after ischemia. Mol. Ther. Nucleic Acids 2019, 14, 329–338. [Google Scholar] [CrossRef]
- Wang, P.; Luo, Y.; Duan, H.; Xing, S.; Zhang, J.; Lu, D.; Feng, J.; Yang, N.; Song, L.; Yan, X. MicroRNA 329 suppresses angiogenesis by targeting CD146. Mol. Cell. Biol. 2013, 33, 3689–3699. [Google Scholar] [CrossRef] [PubMed]
- Idrovo, J.P.; Jacob, A.; Yang, W.L.; Wang, Z.; Yen, H.T.; Nicastro, J.; Coppa, G.F.; Wang, P. A deficiency in cold-inducible RNA-binding protein accelerates the inflammation phase and improves wound healing. Int. J. Mol. Med. 2016, 37, 423–428. [Google Scholar] [CrossRef] [PubMed]
- Limbourg, A.; Korff, T.; Napp, L.C.; Schaper, W.; Drexler, H.; Limbourg, F.P. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat. Protoc. 2009, 4, 1737–1748. [Google Scholar] [CrossRef] [PubMed]
- Olfert, I.M.; Baum, O.; Hellsten, Y.; Egginton, S. Advances and challenges in skeletal muscle angiogenesis. Am. J. Physiol. Circ. Physiol. 2016, 310, H326–H336. [Google Scholar] [CrossRef]
- Kumar, A.; D’Souza, S.S.; Moskvin, O.V.; Toh, H.; Wang, B.; Zhang, J.; Swanson, S.; Guo, L.-W.; Thomson, J.A.; Slukvin, I.I. Specification and diversification of pericytes and smooth muscle cells from mesenchymoangioblasts. Cell Rep. 2017, 19, 1902–1916. [Google Scholar] [CrossRef] [PubMed]
- Attwell, D.; Mishra, A.; Hall, C.N.; O’Farrell, F.M.; Dalkara, T. What is a pericyte? J. Cereb. Blood Flow Metab. 2016, 36, 451–455. [Google Scholar] [CrossRef]
- Shepro, D.; Morel, N.M.L. Pericyte physiology. FASEB J. 1993, 7, 1031–1038. [Google Scholar] [CrossRef] [PubMed]
- He, L.; Vanlandewijck, M.; Raschperger, E.; Mäe, M.A.; Jung, B.; Lebouvier, T.; Ando, K.; Hofmann, J.; Keller, A.; Betsholtz, C. Analysis of the brain mural cell transcriptome. Sci. Rep. 2016, 6, 35108. [Google Scholar] [CrossRef]
- Chillo, O.; Kleinert, E.C.; Lautz, T.; Lasch, M.; Pagel, J.-I.; Heun, Y.; Troidl, K.; Fischer, S.; Caballero-Martinez, A.; Mauer, A.; et al. Perivascular mast cells govern shear stress-induced arteriogenesis by orchestrating leukocyte function. Cell Rep. 2016, 16, 2197–2207. [Google Scholar] [CrossRef]
- Du Cheyne, C.; Tay, H.; De Spiegelaere, W. The complex TIE between macrophages and angiogenesis. Anat. Histol. Embryol. 2019, 49, 585–596. [Google Scholar] [CrossRef]
- Seignez, C.; Phillipson, M. The multitasking neutrophils and their involvement in angiogenesis. Curr. Opin. Hematol. 2017, 24, 3–8. [Google Scholar] [CrossRef]
- Wang, J. Neutrophils in tissue injury and repair. Cell Tissue Res. 2018, 371, 531–539. [Google Scholar] [CrossRef]
- Castanheira, F.V.S.; Kubes, P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood 2019, 133, 2178–2185. [Google Scholar] [CrossRef] [PubMed]
- Pittman, K.; Kubes, P. Damage-associated molecular patterns control neutrophil recruitment. J. Innate Immun. 2013, 5, 315–323. [Google Scholar] [CrossRef] [PubMed]
- Denning, N.-L.; Aziz, M.; Murao, A.; Gurien, S.D.; Ochani, M.; Prince, J.M.; Wang, P. Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis. JCI Insight 2020, 5. [Google Scholar] [CrossRef]
- Yang, W.-L.; Sharma, A.; Wang, Z.; Li, Z.; Fan, J.; Wang, P. Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome. Sci. Rep. 2016, 6, 26571. [Google Scholar] [CrossRef]
- Wellmann, S.; Bührer, C.; Moderegger, E.; Zelmer, A.; Kirschner, R.; Koehne, P.; Fujita, J.; Seeger, K. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. J. Cell Sci. 2004, 117, 1785–1794. [Google Scholar] [CrossRef] [PubMed]
- Wang, J.; Hossain, M.; Thanabalasuriar, A.; Gunzer, M.; Meininger, C.; Kubes, P. Visualizing the function and fate of neutrophils in sterile injury and repair. Science 2017, 358, 111–116. [Google Scholar] [CrossRef]
- Murray, P.J. Macrophage polarization. Annu. Rev. Physiol. 2017, 79, 541–566. [Google Scholar] [CrossRef] [PubMed]
- Duffield, J.S.; Forbes, S.J.; Constandinou, C.M.; Clay, S.; Partolina, M.; Vuthoori, S.; Wu, S.; Lang, R.; Iredale, J.P. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Investig. 2005, 115, 56–65. [Google Scholar] [CrossRef]
- Lucas, T.; Waisman, A.; Ranjan, R.; Roes, J.; Krieg, T.; Müller, W.; Roers, A.; Eming, S.A. Differential roles of macrophages in diverse phases of skin repair. J. Immunol. 2010, 184, 3964–3977. [Google Scholar] [CrossRef]
- Hong, H.; Tian, X.Y. The role of macrophages in vascular repair and regeneration after ischemic injury. Int. J. Mol. Sci. 2020, 21, 6328. [Google Scholar] [CrossRef] [PubMed]
- Gurevich, D.B.; E Severn, C.; Twomey, C.; Greenhough, A.; Cash, J.; Toye, A.M.; Mellor, H.; Martin, P. Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. EMBO J. 2018, 37. [Google Scholar] [CrossRef] [PubMed]
- Goel, H.L.; Mercurio, A.M. VEGF targets the tumour cell. Nat. Rev. Cancer 2013, 13, 871–882. [Google Scholar] [CrossRef]
- Zajac, E.; Schweighofer, B.; Kupriyanova, T.A.; Juncker-Jensen, A.; Minder, P.; Quigley, J.P.; Deryugina, E.I. Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9. Blood 2013, 122, 4054–4067. [Google Scholar] [CrossRef]
- Zhang, J.; Muri, J.; Fitzgerald, G.; Gorski, T.; Gianni-Barrera, R.; Masschelein, E.; D’Hulst, G.; Gilardoni, P.; Turiel, G.; Fan, Z.; et al. Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization. Cell Metab. 2020, 31, 1136–1153.e7. [Google Scholar] [CrossRef]
- Willenborg, S.; Lucas, T.; Van Loo, G.; Knipper, J.A.; Krieg, T.; Haase, I.; Brachvogel, B.; Hammerschmidt, M.; Nagy, A.; Ferrara, N.; et al. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 2012, 120, 613–625. [Google Scholar] [CrossRef]
- Dort, J.; Fabre, P.; Molina, T.; Dumont, N.A. Macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases. Stem Cells Int. 2019, 2019, 4761427. [Google Scholar] [CrossRef]
- Gordon, S.; Martinez, F.O. Alternative activation of macrophages: Mechanism and functions. Immunity 2010, 32, 593–604. [Google Scholar] [CrossRef] [PubMed]
- Moore, E.M.; West, J.L. Harnessing macrophages for vascularization in tissue engineering. Ann. Biomed. Eng. 2018, 47, 354–365. [Google Scholar] [CrossRef]
- Gordon, S.; Taylor, P.R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 2005, 5, 953–964. [Google Scholar] [CrossRef] [PubMed]
- Pollard, J.W. Trophic macrophages in development and disease. Nat. Rev. Immunol. 2009, 9, 259–270. [Google Scholar] [CrossRef] [PubMed]
- Li, G.; Yang, L.; Yuan, H.; Liu, Y.; He, Y.; Wu, X.; Jin, X. Cold-inducible RNA-binding protein plays a central role in the pathogenesis of abdominal aortic aneurysm in a murine experimental model. Surgery 2016, 159, 1654–1667. [Google Scholar] [CrossRef]
- Zhou, M.; Aziz, M.; Denning, N.-L.; Yen, H.-T.; Ma, G.; Wang, P. Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R–mediated STAT3 activation. JCI Insight 2020, 5. [Google Scholar] [CrossRef]
- Ardi, V.C.; Kupriyanova, T.A.; Deryugina, E.I.; Quigley, J.P. Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis. Proc. Natl. Acad. Sci. USA 2007, 104, 20262–20267. [Google Scholar] [CrossRef] [PubMed]
- Gong, Y.; Koh, D.-R. Neutrophils promote inflammatory angiogenesis via release of preformed VEGF in an in vivo corneal model. Cell Tissue Res. 2009, 339, 437–448. [Google Scholar] [CrossRef]
- Christoffersson, G.; Vågesjö, E.; Vandooren, J.; Lidén, M.; Massena, S.; Reinert, R.B.; Brissova, M.; Powers, A.C.; Opdenakker, G.; Phillipson, M. VEGF-A recruits a proangiogenic MMP-9–delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Blood 2012, 120, 4653–4662. [Google Scholar] [CrossRef]
- Kolaczkowska, E.; Kubes, P. Neutrophil recruitment and function in health and inflammation. Nat. Rev. Immunol. 2013, 13, 159–175. [Google Scholar] [CrossRef] [PubMed]
- Pizza, F.X.; Peterson, J.M.; Baas, J.H.; Koh, T.J. Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice. J. Physiol. 2005, 562, 899–913. [Google Scholar] [CrossRef]
- Toumi, H.; F’Guyer, S.; Best, T.M. The role of neutrophils in injury and repair following muscle stretch. J. Anat. 2006, 208, 459–470. [Google Scholar] [CrossRef]
- Teixeira, C.D.F.; Zamunér, S.R.; Zuliani, J.P.; Fernandes, C.M.; Höfling, M.A.C.; Fernandes, I.; Chaves, F.; Gutiérrez, J.M. Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops aspersnake venom. Muscle Nerve 2003, 28, 449–459. [Google Scholar] [CrossRef]
- De Oliveira, S.; Rosowski, E.E.; Huttenlocher, A. Neutrophil migration in infection and wound repair: Going forward in reverse. Nat. Rev. Immunol. 2016, 16, 378–391. [Google Scholar] [CrossRef] [PubMed]
- Jin, H.; Aziz, M.; Ode, Y.; Wang, P. CIRP induces neutrophil reverse transendothelial migration in sepsis. Shock 2019, 51, 548–556. [Google Scholar] [CrossRef] [PubMed]
- Slaba, I.; Wang, J.; Kolaczkowska, E.; McDonald, B.; Lee, W.-Y.; Kubes, P. Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice. Hepatology 2015, 62, 1593–1605. [Google Scholar] [CrossRef] [PubMed]
- Chen, K.; Murao, A.; Arif, A.; Takizawa, S.; Jin, H.; Jiang, J.; Aziz, M.; Wang, P. Inhibition of efferocytosis by extracellular CIRP–induced neutrophil extracellular traps. J. Immunol. 2021, 206, 797–806. [Google Scholar] [CrossRef] [PubMed]
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Kübler, M.; Beck, S.; Fischer, S.; Götz, P.; Kumaraswami, K.; Ishikawa-Ankerhold, H.; Lasch, M.; Deindl, E. Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines 2021, 9, 395. https://doi.org/10.3390/biomedicines9040395
Kübler M, Beck S, Fischer S, Götz P, Kumaraswami K, Ishikawa-Ankerhold H, Lasch M, Deindl E. Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines. 2021; 9(4):395. https://doi.org/10.3390/biomedicines9040395
Chicago/Turabian StyleKübler, Matthias, Sebastian Beck, Silvia Fischer, Philipp Götz, Konda Kumaraswami, Hellen Ishikawa-Ankerhold, Manuel Lasch, and Elisabeth Deindl. 2021. "Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization" Biomedicines 9, no. 4: 395. https://doi.org/10.3390/biomedicines9040395
APA StyleKübler, M., Beck, S., Fischer, S., Götz, P., Kumaraswami, K., Ishikawa-Ankerhold, H., Lasch, M., & Deindl, E. (2021). Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines, 9(4), 395. https://doi.org/10.3390/biomedicines9040395