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Article

Comparison of Oxidative and Hypoxic Stress Responsive Genes from Meta-Analysis of Public Transcriptomes

Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 3-10-23 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan
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Academic Editors: Fabio Altieri and David R. Wallace
Biomedicines 2021, 9(12), 1830; https://doi.org/10.3390/biomedicines9121830
Received: 2 November 2021 / Revised: 23 November 2021 / Accepted: 30 November 2021 / Published: 3 December 2021
(This article belongs to the Section Molecular Genetics and Genetic Diseases)
Analysis of RNA-sequencing (RNA-seq) data is an effective means to analyze the gene expression levels under specific conditions and discover new biological knowledge. More than 74,000 experimental series with RNA-seq have been stored in public databases as of 20 October 2021. Since this huge amount of expression data accumulated from past studies is a promising source of new biological insights, we focused on a meta-analysis of 1783 runs of RNA-seq data under the conditions of two types of stressors: oxidative stress (OS) and hypoxia. The collected RNA-seq data of OS were organized as the OS dataset to retrieve and analyze differentially expressed genes (DEGs). The OS-induced DEGs were compared with the hypoxia-induced DEGs retrieved from a previous study. The results from the meta-analysis of OS transcriptomes revealed two genes, CRIP1 and CRIP3, which were particularly downregulated, suggesting a relationship between OS and zinc homeostasis. The comparison between meta-analysis of OS and hypoxia showed that several genes were differentially expressed under both stress conditions, and it was inferred that the downregulation of cell cycle-related genes is a mutual biological process in both OS and hypoxia. View Full-Text
Keywords: oxidative stress; RNA-seq; meta-analysis; hypoxia oxidative stress; RNA-seq; meta-analysis; hypoxia
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MDPI and ACS Style

Suzuki, T.; Ono, Y.; Bono, H. Comparison of Oxidative and Hypoxic Stress Responsive Genes from Meta-Analysis of Public Transcriptomes. Biomedicines 2021, 9, 1830. https://doi.org/10.3390/biomedicines9121830

AMA Style

Suzuki T, Ono Y, Bono H. Comparison of Oxidative and Hypoxic Stress Responsive Genes from Meta-Analysis of Public Transcriptomes. Biomedicines. 2021; 9(12):1830. https://doi.org/10.3390/biomedicines9121830

Chicago/Turabian Style

Suzuki, Takayuki, Yoko Ono, and Hidemasa Bono. 2021. "Comparison of Oxidative and Hypoxic Stress Responsive Genes from Meta-Analysis of Public Transcriptomes" Biomedicines 9, no. 12: 1830. https://doi.org/10.3390/biomedicines9121830

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