Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far?
Round 1
Reviewer 1 Report
The manuscript is written in an acceptable way. I recommended some comments to improve the quality of the manuscript for the readers of the journal.
- The introduction section is too short and needs to rewrite in a new form.
- Section 6. Please bring the full form of the following:
IL-1, IL-6, IL-7, IL-8, IL-10, IL12, IL-15, IL-18, IL-20
- Section 7.4.8
One of the main drugs to treat HSV is known as Acyclovir which has been used as a drug in vaginal drug delivery studies. I recommend to the authors to use the following reference in this manuscript also.
Sabbagh, F., & Muhamad, I. I. (2017). Acrylamide-based hydrogel drug delivery systems: release of acyclovir from MgO nanocomposite hydrogel. Journal of the Taiwan Institute of Chemical Engineers, 72, 182-193.
- Section 7.4. please explain more each section and compare recent studies together.
- Section 9. It is supposed to add “future prospects to this section”.
- I recommend replacing too old references with newly published references.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript is well-organized, and it contains interesting view point to the readers of the journal.
However, they include non-soluble factors, such as receptors, into their "soluble factors" title, which should be changed.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
