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Article

Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone

1
Department of Neurosurgery, University Medical Center Mainz, 55131 Mainz, Germany
2
Max Planck Institute for Polymer Research, 55128 Mainz, Germany
3
Center for Translational Nanomedicine, University Medical Center Mainz, 55131 Maniz, Germany
4
Personalized Biomedical Engineering Lab, Frankfurt University of Applied Sciences, 60318 Frankfurt am Main, Germany
5
Department of Neuroradiology, University Medical Center Mainz, 55131 Mainz, Germany
6
Department of Radiology, University Medical Center Mainz, 55131 Mainz, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Peer Wolfgang Kämmerer and Bilal Al-Nawas
Biomedicines 2021, 9(10), 1392; https://doi.org/10.3390/biomedicines9101392
Received: 31 August 2021 / Revised: 27 September 2021 / Accepted: 28 September 2021 / Published: 4 October 2021
Osteoporotic vertebral fractures often necessitate fusion surgery, with high rates of implant failure. We present a novel bioactive composite of calcium phosphate cement (CPC) and the collagen I mimetic P-15 for pedicle screw augmentation in osteoporotic bone. Methods involved expression analysis of osteogenesis-related genes during osteoblastic differentiation by RT-PCR and immunostaining of osteopontin and Ca2+ deposits. Untreated and decalcified sheep vertebrae were utilized for linear pullout testing of pedicle screws. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA). Expression of ALPI II (p < 0.0001), osteopontin (p < 0.0001), RUNX2 (p < 0.0001), and osteocalcin (p < 0.0001) was upregulated after co-culture of MSC with CPC-P-15. BMD was decreased by 28.75% ± 2.6%. Pullout loads in untreated vertebrae were 1405 ± 6 N (p < 0.001) without augmentation, 2010 ± 168 N (p < 0.0001) after augmentation with CPC-P-15, and 2112 ± 98 N (p < 0.0001) with PMMA. In decalcified vertebrae, pullout loads were 828 ± 66 N (p < 0.0001) without augmentation, 1324 ± 712 N (p = 0.04) with PMMA, and 1252 ± 131 N (p < 0.0078) with CPC-P-15. CPC-P-15 induces osteoblastic differentiation of human MES and improves pullout resistance of pedicle screws in osteoporotic and non-osteoporotic bone. View Full-Text
Keywords: osteoporosis; osteoporotic vertebral fractures; polymethylmethacrylate; calcium phosphate cement; collagen I mimetic P-15 osteoporosis; osteoporotic vertebral fractures; polymethylmethacrylate; calcium phosphate cement; collagen I mimetic P-15
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MDPI and ACS Style

Krenzlin, H.; Foelger, A.; Mailänder, V.; Blase, C.; Brockmann, M.; Düber, C.; Ringel, F.; Keric, N. Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone. Biomedicines 2021, 9, 1392. https://doi.org/10.3390/biomedicines9101392

AMA Style

Krenzlin H, Foelger A, Mailänder V, Blase C, Brockmann M, Düber C, Ringel F, Keric N. Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone. Biomedicines. 2021; 9(10):1392. https://doi.org/10.3390/biomedicines9101392

Chicago/Turabian Style

Krenzlin, Harald, Andrea Foelger, Volker Mailänder, Christopher Blase, Marc Brockmann, Christoph Düber, Florian Ringel, and Naureen Keric. 2021. "Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone" Biomedicines 9, no. 10: 1392. https://doi.org/10.3390/biomedicines9101392

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