Next Article in Journal
Dibenzoylthiamine Has Powerful Antioxidant and Anti-Inflammatory Properties in Cultured Cells and in Mouse Models of Stress and Neurodegeneration
Previous Article in Journal
High-Dimensional Analysis of Immune Cell Composition Predicts Periprosthetic Joint Infections and Dissects Its Pathophysiology
 
 
Article

A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children

1
Pediatric Unit, Hospital Materno-Infantil, Ciudad Sanitaria Virgen de las Nieves, 18014 Granada, Spain
2
Pediatric Allergology Unit, Hospital Materno-Infantil, Ciudad Sanitaria Virgen de las Nieves, 18014 Granada, Spain
3
Department of Microbiology, Complejo Hospitalario de Granada, 18012 Granada, Spain
4
ibs.GRANADA, Instituto de Investigación Biosanitaria, 18012 Granada, Spain
5
Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD12/0026/0015) Instituo de Salud Carlos III, 28029 Madrid, Spain
6
Department of Biochemistry and Molecular Biology II, School of Pharmacy, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, 18160 Granada, Spain
7
Pediatric Unit, San Cecilio University Hospital, 18012 Granada, Spain
8
CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III, 28029 Madrid, Spain
9
Unit of Pediatric Endocrinology, Reina Sofia University Hospital, 14004 Córdoba, Spain
10
Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, Denmark
11
Estación Experimental de Zonas Áridas, Consejo Superior de Investigaciones Cientificas (EEZA-CSIC), Carretera de Sacramento s/n, La Canada de San Urbano, 04120 Almería, Spain
12
Department of Signal Theory, Networking and Communications, University of Granada, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(9), 359; https://doi.org/10.3390/biomedicines8090359
Received: 22 July 2020 / Revised: 26 August 2020 / Accepted: 14 September 2020 / Published: 18 September 2020
(This article belongs to the Section Molecular and Translational Medicine)
Background: Asthma is a multifactorial condition where patients with identical clinical diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota signatures that characterize the clinical allergic asthma phenotype in obese children. Methods: We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers, metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover, allergic children with a worse asthma outcome showed higher levels of large unstained cells, fecal D lactate and D/L lactate ratio, and with a higher relative proportion of plasma creatinine and an unclassified family member from the RF39 order belonging to the Mollicutes class. Otherwise, children with persistent asthma presented lower levels of plasma citrate and dimethylsulfone. Conclusion: Our integrative approach shows the molecular heterogeneity of the allergic asthma phenotype while highlighting the use of omics technologies to examine the clinical phenotype at a more holistic level. View Full-Text
Keywords: asthma; gastrointestinal microbiome; metabolomics; multi-omics approach asthma; gastrointestinal microbiome; metabolomics; multi-omics approach
Show Figures

Figure 1

MDPI and ACS Style

Gomez-Llorente, M.A.; Martínez-Cañavate, A.; Chueca, N.; Rico, M.d.l.C.; Romero, R.; Anguita-Ruiz, A.; Aguilera, C.M.; Gil-Campos, M.; Mesa, M.D.; Khakimov, B.; Morillo, J.A.; Gil, Á.; Camacho, J.; Gomez-Llorente, C. A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children. Biomedicines 2020, 8, 359. https://doi.org/10.3390/biomedicines8090359

AMA Style

Gomez-Llorente MA, Martínez-Cañavate A, Chueca N, Rico MdlC, Romero R, Anguita-Ruiz A, Aguilera CM, Gil-Campos M, Mesa MD, Khakimov B, Morillo JA, Gil Á, Camacho J, Gomez-Llorente C. A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children. Biomedicines. 2020; 8(9):359. https://doi.org/10.3390/biomedicines8090359

Chicago/Turabian Style

Gomez-Llorente, Mª Amelia, Ana Martínez-Cañavate, Natalia Chueca, Mª de la Cruz Rico, Raquel Romero, Augusto Anguita-Ruiz, Concepción Mª Aguilera, Mercedes Gil-Campos, Maria D Mesa, Bekzod Khakimov, Jose Antonio Morillo, Ángel Gil, José Camacho, and Carolina Gomez-Llorente. 2020. "A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children" Biomedicines 8, no. 9: 359. https://doi.org/10.3390/biomedicines8090359

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop