Next Article in Journal
Image Analysis of 3D Conjunctival Melanoma Cell Cultures Following Electrochemotherapy
Previous Article in Journal
Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma
Open AccessArticle

Dose-Independent Therapeutic Benefit of Bone Marrow Stem Cell Transplantation after MI in Mice

by Nicole Zarniko 1,†, Anna Skorska 1,2,†, Gustav Steinhoff 1,2, Robert David 1,2,* and Ralf Gaebel 1,2
1
Department of Cardiac Surgery, Rostock University Medical Center, 18059 Rostock, Germany
2
Department Life, Light & Matter (LL&M), University of Rostock, A.-Einstein-Str. 25, 18057 Rostock, Germany
*
Author to whom correspondence should be addressed.
Authors contributed equally to this work.
Biomedicines 2020, 8(6), 157; https://doi.org/10.3390/biomedicines8060157
Received: 19 May 2020 / Revised: 8 June 2020 / Accepted: 9 June 2020 / Published: 11 June 2020
(This article belongs to the Section Gene and Cell Therapy)
Several cell populations derived from bone marrow (BM) have been shown to possess cardiac regenerative potential. Among these are freshly isolated CD133+ hematopoietic as well as culture-expanded mesenchymal stem cells. Alternatively, by purifying CD271+ cells from BM, mesenchymal progenitors can be enriched without an ex vivo cultivation. With regard to the limited available number of freshly isolated BM-derived stem cells, the effect of the dosage on the therapeutic efficiency is of particular interest. Therefore, in the present pre-clinical study, we investigated human BM-derived CD133+ and CD271+ stem cells for their cardiac regenerative potential three weeks post-myocardial infarction (MI) in a dose-dependent manner. The improvement of the hemodynamic function as well as cardiac remodeling showed no therapeutic difference after the transplantation of both 100,000 and 500,000 stem cells. Therefore, beneficial stem cell transplantation post-MI is widely independent of the cell dose and detrimental stem cell amplification in vitro can likely be avoided. View Full-Text
Keywords: myocardial infarction; stem cells; autologous cell therapy; pre-clinical; scientific advance myocardial infarction; stem cells; autologous cell therapy; pre-clinical; scientific advance
Show Figures

Figure 1

MDPI and ACS Style

Zarniko, N.; Skorska, A.; Steinhoff, G.; David, R.; Gaebel, R. Dose-Independent Therapeutic Benefit of Bone Marrow Stem Cell Transplantation after MI in Mice. Biomedicines 2020, 8, 157.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop