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Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma

1
Department of Dermatology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
2
Anatomic Pathology Unit, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
3
Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(6), 156; https://doi.org/10.3390/biomedicines8060156
Received: 18 May 2020 / Revised: 8 June 2020 / Accepted: 9 June 2020 / Published: 11 June 2020
(This article belongs to the Section Tumor Cell Biology)
The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors. However, given the burden of mutations in the tumor microenvironment and lack of knowledge for the follow-up of advanced basal cell carcinoma, we are proposing a possible synergistic therapeutic application. Our aim is to underline the use of arsenic trioxide, itraconazole, all-trans-retinoic acid and nicotinamide as possible adjuvant therapies either in advanced not responding basal cell carcinoma or during follow-up based on Hedgehog pathway. We have analyzed the rational use of these drugs as a pivotal point to block neoplasm progression, modulate epigenetic modification and prevent recurrences. View Full-Text
Keywords: arsenic trioxide; basal cell carcinoma; Hedgehog signaling pathway; itraconazole; nicotinamide; retinoic acid; smoothened receptors arsenic trioxide; basal cell carcinoma; Hedgehog signaling pathway; itraconazole; nicotinamide; retinoic acid; smoothened receptors
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Cosio, T.; Di Prete, M.; Campione, E. Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Biomedicines 2020, 8, 156.

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