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Article

Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression

1
Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
2
Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(3), 45; https://doi.org/10.3390/biomedicines8030045
Received: 7 February 2020 / Revised: 23 February 2020 / Accepted: 25 February 2020 / Published: 27 February 2020
Amyloid precursor protein (APP) is directly related to Aβ amyloidosis—a hallmark of Alzheimer’s disease (AD). However, the impact of environmental factors upon APP biology and Aβ amyloid pathology have not been well studied. The increased use of nanoparticles (NPs) or engineered nanomaterials (ENMs) has led to a growing body of evidence suggesting that exposure to metal/metal oxide NPs, such as Fe2O3, CuO, and ZnO, may contribute to the pathophysiology of neurodegenerative diseases such as AD through neuroinflammation. Our previous studies indicated that exposure to CuO nanoparticles (CuONPs) induce potent in vitro neurotoxicity. Herein, we investigated the effects on APP expression in neuronal cells exposed to different metal oxide NPs. We found a low dose of CuONPs effectively activated the NFκB signaling pathway and increased APP expression. Moreover, the inhibition of p65 expression using siRNA abolished CuONP-mediated APP expression, suggesting that NFκB-regulated APP expression in response to CuONP exposure may be associated with AD pathology. View Full-Text
Keywords: Alzheimer’s disease; NFκB; IκBα; Aβ; amyloid precursor protein; nanoparticles; engineered nanomaterials; nanoneurotoxicity Alzheimer’s disease; NFκB; IκBα; ; amyloid precursor protein; nanoparticles; engineered nanomaterials; nanoneurotoxicity
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MDPI and ACS Style

Mou, X.; Pilozzi, A.; Tailor, B.; Yi, J.; Cahill, C.; Rogers, J.; Huang, X. Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression. Biomedicines 2020, 8, 45. https://doi.org/10.3390/biomedicines8030045

AMA Style

Mou X, Pilozzi A, Tailor B, Yi J, Cahill C, Rogers J, Huang X. Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression. Biomedicines. 2020; 8(3):45. https://doi.org/10.3390/biomedicines8030045

Chicago/Turabian Style

Mou, Xiaoyang, Alexander Pilozzi, Breeya Tailor, Jing Yi, Catherine Cahill, Jack Rogers, and Xudong Huang. 2020. "Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression" Biomedicines 8, no. 3: 45. https://doi.org/10.3390/biomedicines8030045

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