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Review

Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives

1
Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India
2
School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh 173229, India
3
Department of Biology, Faculty of Science, Selcuk University Campus, Konya 42250, Turkey
4
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
5
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania
*
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(12), 571; https://doi.org/10.3390/biomedicines8120571
Received: 20 November 2020 / Revised: 1 December 2020 / Accepted: 4 December 2020 / Published: 6 December 2020
(This article belongs to the Special Issue Natural Medicine in Therapy)
Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science. Cancer, being considered a “hopeless case and the leading cause of death worldwide, and the available conventional therapies have many lacunae in the form of side effects. The poly pharmaceutical natural compound, WA treatment, displayed attenuation of various cancer hallmarks by altering oxidative stress, promoting apoptosis, and autophagy, inhibiting cell proliferation, reducing angiogenesis, and metastasis progression. The cellular proteins associated with antitumor pathways were also discussed. WA structural modifications attack multiple signal transduction pathways and enhance the therapeutic outcomes in various diseases. Moreover, it has shown validated pharmacological effects against multiple neurodegenerative diseases by inhibiting acetylcholesterinases and butyrylcholinesterases enzyme activity, antidiabetic activity by upregulating adiponectin and preventing the phosphorylation of peroxisome proliferator-activated receptors (PPARγ), cardioprotective activity by AMP-activated protein kinase (AMPK) activation and suppressing mitochondrial apoptosis. The current review is an extensive survey of various WA associated disease targets, its pharmacokinetics, synergistic combination, modifications, and biological activities. View Full-Text
Keywords: Withaferin A; anticancer; autophagy; chaperone Withaferin A; anticancer; autophagy; chaperone
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MDPI and ACS Style

Behl, T.; Sharma, A.; Sharma, L.; Sehgal, A.; Zengin, G.; Brata, R.; Fratila, O.; Bungau, S. Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives. Biomedicines 2020, 8, 571. https://doi.org/10.3390/biomedicines8120571

AMA Style

Behl T, Sharma A, Sharma L, Sehgal A, Zengin G, Brata R, Fratila O, Bungau S. Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives. Biomedicines. 2020; 8(12):571. https://doi.org/10.3390/biomedicines8120571

Chicago/Turabian Style

Behl, Tapan, Aditi Sharma, Lalit Sharma, Aayush Sehgal, Gokhan Zengin, Roxana Brata, Ovidiu Fratila, and Simona Bungau. 2020. "Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives" Biomedicines 8, no. 12: 571. https://doi.org/10.3390/biomedicines8120571

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