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Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention

1
Center for Neuroscience, Korea Institute of Science and Technology (KIST), 5 Hwarang-ro 14-gil, Seoul 02792, Korea
2
Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh
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ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh
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Department of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh
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Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh
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Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore 7408, Bangladesh
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Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh
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Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
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Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Seoul 03722, Korea
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Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Korea
*
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(11), 517; https://doi.org/10.3390/biomedicines8110517
Received: 15 October 2020 / Revised: 12 November 2020 / Accepted: 12 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue Natural Medicine in Therapy)
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, cardiovascular disease, diabetes, and malignancies. Recently, natural compounds have come to attention for being able to modulate the autophagy pathway in cancer prevention, although the prospective role of autophagy in cancer treatment is very complex and not yet clearly elucidated. Numerous synthetic chemicals have been identified that modulate autophagy and are favorable candidates for cancer treatment, but they have adverse side effects. Therefore, different phytochemicals, which include natural compounds and their derivatives, have attracted significant attention for use as autophagy modulators in cancer treatment with minimal side effects. In the current review, we discuss the promising role of natural compounds in modulating the autophagy pathway to control and prevent cancer, and provide possible therapeutic options. View Full-Text
Keywords: autophagy; cancer; phytochemical; natural compound; treatment autophagy; cancer; phytochemical; natural compound; treatment
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MDPI and ACS Style

Rahman, M.A.; Rahman, M.H.; Hossain, M.S.; Biswas, P.; Islam, R.; Uddin, M.J.; Rahman, M.H.; Rhim, H. Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention. Biomedicines 2020, 8, 517. https://doi.org/10.3390/biomedicines8110517

AMA Style

Rahman MA, Rahman MH, Hossain MS, Biswas P, Islam R, Uddin MJ, Rahman MH, Rhim H. Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention. Biomedicines. 2020; 8(11):517. https://doi.org/10.3390/biomedicines8110517

Chicago/Turabian Style

Rahman, Md. Ataur, MD. Hasanur Rahman, Md. Shahadat Hossain, Partha Biswas, Rokibul Islam, Md Jamal Uddin, Md. Habibur Rahman, and Hyewhon Rhim. 2020. "Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention" Biomedicines 8, no. 11: 517. https://doi.org/10.3390/biomedicines8110517

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